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Donepezil
go.drugbank.com/drugs/DB00843ApprovedInvestigationalIn 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholineste...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Donepezil G.L. 5 mg - Schmelztabletten, Donepezil G.L. 10 mg - SchmelztablettenDuloxetine
go.drugbank.com/drugs/DB00476ApprovedInvestigationalDuloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymb...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: Duloxetin G.L. 30 mg-magensaftresistente Hartkapseln, Duloxetin G.L. 60 mg-magensaftresistente HartkapselnNitisinone
go.drugbank.com/drugs/DB00348ApprovedIt is sold under the brand names Orfadin and Harliku. [L53253, L53258]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 2-(alpha,alpha,alpha-Trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedioneGuanosine
go.drugbank.com/drugs/DB02857InvestigationalGuanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanos...
Synonyms: GuoLosartan
go.drugbank.com/drugs/DB00678ApprovedInvestigationalLosartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associate...
Mixtures: LORZAAR PL FORTE100/12.5MG, Losartan-HCT G.L. 100mg/25 mg - FilmtablettenCategories: P-glycoprotein inhibitors, P-glycoprotein substratesAtezolizumab
go.drugbank.com/drugs/DB11595ApprovedInvestigationalAtezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers. … [A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy.
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitorsOctinoxate
go.drugbank.com/drugs/DB09496ApprovedInvestigationalOctinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage. It was originally developed in 1950's as an organic UV-B filter that absorbs UV-B rays from sun. It is often com...
Mixtures: Select Brand Sunscreen, Life Brand Sunblock 15 SPFSynonyms: ethylhexyl p-methoxycinnamateCabozantinib
go.drugbank.com/drugs/DB08875ApprovedInvestigationalIt was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsMethylphenidate
go.drugbank.com/drugs/DB00422ApprovedInvestigationalMethylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylp...
Products: Jornay PM, JORNAY PM Extended-ReleaseLopinavir
go.drugbank.com/drugs/DB01601ApprovedInvestigational[L11163] Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to lopinavir's
Categories: P-glycoprotein inducers, P-glycoprotein inhibitors