Octinoxate is a sunscreen agent found in sunscreens that absorbs UV rays. Octinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage.
- Mechanism
- Curator reviewed · 2 references
Absorbs UV-B (predominantly) and UV-A rays while accumulating in the outermost layer of the epidermis. Like any other photoprotective agents, octinoxate prevents the damage to cells and deoxyribonucleic acid (DNA) by reducing the p53 protein expression following UV exposure and also increases the skin's tolerability to UV rays.
- Primary indication
- As an active ingredient in sunscreens and lip balms.Curator reviewed · 3 structured indications
- Formula / weight
- C18H26O3 · 290.3972 g/mol (avg)
- First approval
- Canada, 1996 · United States, 2000
- Also known as
- ethylhexyl methoxycinnamate · ethylhexyl p-methoxycinnamate · octyl methoxycinnamate · parsol
- Code names
- Eusolex 2292 · Uvinul MC80
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
YBGZDTIWKVFICR-JLHYYAGUSA-NSMILES[H]\C(=C(\[H])C1=CC=C(OC)C=C1)C(=O)OCC(CC)CCCCTargets
What you can answer from here — as of July 06, 2026
2Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Octinoxate, and which of those have an active Phase 3 trial?
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