Octinoxate is a sunscreen agent found in sunscreens that absorbs UV rays.
- Brand Names
- Eucerin, Meijer, Sumadan Wash
- Generic Name
- DrugBank Accession Number
Octinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage. It was originally developed in 1950's as an organic UV-B filter that absorbs UV-B rays from sun. It is often combined with nanoparticles or other water-resistant liposomes in formulations to increase the localization at the epidermis and decrease the risk of percutaneous absorption. Its use in pharmaceutical and cosmetic formulations is approved by FDA.
- Small Molecule
- Approved, Investigational
- Average: 290.3972
- Chemical Formula
- ethylhexyl methoxycinnamate
- ethylhexyl p-methoxycinnamate
- octyl methoxycinnamate
- External IDs
- Eusolex 2292
- Uvinul MC80
As an active ingredient in sunscreens and lip balms. Used for protection against damaging effects of sun rays.Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.
- Associated Conditions
- Contraindications & Blackbox Warnings
- Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.
Acts as a photoprotective agent that protects the skin by preventing and minimizing the damaging effects of ultraviolet (UV) rays of natural light. The cellular effects of UV irradiation include DNA damage, cell cycle arrest, immunological depression, apoptosis, and transcriptional changes 7.
- Mechanism of action
Absorbs UV-B (predominantly) and UV-A rays while accumulating in the outermost layer of the epidermis. Like any other photoprotective agents, octinoxate prevents the damage to cells and deoxyribonucleic acid (DNA) by reducing the p53 protein expression following UV exposure 7 and also increases the skin's tolerability to UV rays 6.
Can be systemically absorbed after skin application, being found in the deeper layers of the stratum corneum as well as urine, plasma, and breast milk 2. The mean maximum plasma concentration detected after application of 2mg/cm2 sunscreen was 7ng/mL in women and 16ng/mL in men 6.
- Volume of distribution
- Protein binding
Can undergo hepatic metabolism when systematically absorbed. Can be enzymatically degraded by lipases in the stratum corneum where esters undergo hydrolysis 2. Degrade into photoproducts when exposed to sunlight, which leads to a decrease in UV absorption efficiency 6.
- Route of elimination
Can be detected in urine in unchanged form 4.
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.
Slightly hazardous in case of skin contact, eye contact, ingestion and inhalation. Octinoxate may form reactive singlet oxygen species and induce anti-estrogenic effects 8. UV-induced molecular breakdown of octinoxate may interfere with cellular processes or induce oxidative damage in human skin 6. The NOAEL (no observed adverse effect level) is 450 mg/kg bw/day for fertility and reproductive performance, for systemic parental and developmental toxicity in Wistar rats 3.
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Abacavir Abacavir may decrease the excretion rate of Octinoxate which could result in a higher serum level. Aceclofenac Aceclofenac may decrease the excretion rate of Octinoxate which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Octinoxate which could result in a higher serum level. Acetaminophen Acetaminophen may decrease the excretion rate of Octinoxate which could result in a higher serum level. Acetazolamide Acetazolamide may increase the excretion rate of Octinoxate which could result in a lower serum level and potentially a reduction in efficacy. Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Octinoxate which could result in a higher serum level. Aclidinium Aclidinium may decrease the excretion rate of Octinoxate which could result in a higher serum level. Acrivastine Acrivastine may decrease the excretion rate of Octinoxate which could result in a higher serum level. Acyclovir Acyclovir may decrease the excretion rate of Octinoxate which could result in a higher serum level. Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Octinoxate which could result in a higher serum level.Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more
- Food Interactions
- No interactions found.
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Active Moieties
Name Kind UNII CAS InChI Key 2-Ethylhexyl 4-phenylbenzophenone-2'-carboxylate unknown 93NOD9WBCS 75005-95-7 TWAOKHHZKFMFMD-UHFFFAOYSA-N
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image No7 Protect and Perfect Foundation Sunscreen Broad Spectrum SPF 15 Calico Emulsion 1.5 g/30g Topical Boots Retail Usa Inc 2012-10-26 Not applicable
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 125 Fl Moisture Whip Lipstick-stk Top 50mg/g Stick 50 mg / g Topical Maybelline Canada 1996-12-31 1998-07-11 2-Power Fabric SPF 25 Cream 67 mg/1mL Topical BPS 60 2017-12-25 Not applicable 25 Creme 410 Cream 7.5 % Topical Multaler & Cie 2004-06-01 2008-03-28 275lw Long Wearing Lipstick 50mg/g Stick 50 mg / g Topical Maybelline Canada 1996-12-31 1998-07-11 4-IN-1 Liquid 14-hour Wear Foundation SPF 15 Emulsion 5 % w/w Topical PUR MINERALS 2013-02-20 2017-03-28 6 Creme 410 Cream 5 % Topical Multaler & Cie 2004-12-01 2008-06-25 6 Creme 410 Teintee Cream 5 g/100g Topical MULTALER & CIE S.A.S 2011-02-15 2017-05-11 6 Creme 410 Teintee Cream 5 % Topical Multaler & Cie 2004-12-03 2013-07-31 6 Lait Solaire Lotion 5 % Topical Multaler & Cie 2004-12-01 2013-07-31 675rl Revitalizing Lip Indulgence - Stk 7.5% Stick 7.5 % Topical Maybelline Canada 1996-12-31 1999-07-30
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 01 Balancing Foundation SPF 15 Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 01 Moisture Foundation SPF 15 Octinoxate (3.75 mg/0.5mL) + Zinc oxide (3.9 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 Not applicable 02 Balancing Foundation SPF 15 Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 02 Cushion Spf45 Sunscreen Octinoxate (5 g/100mL) + Octisalate (5 g/100mL) + Octocrylene (2.5 g/100mL) + Titanium dioxide (13.5 g/100mL) + Zinc oxide (8 g/100mL) Liquid Topical COIZ CO LTD 2019-06-30 Not applicable 02 Moisture Foundation SPF 15 Octinoxate (3.75 mg/0.5mL) + Zinc oxide (3.9 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 Not applicable 03 Balancing Foundation SPF 15 Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 03 Moisture Foundation SPF 15 Octinoxate (3.75 mg/0.5mL) + Zinc oxide (3.9 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 Not applicable 04 Balancing Foundation SPF 15 Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 04 Moisture Foundation SPF 15 Octinoxate (3.75 mg/0.5mL) + Zinc oxide (3.9 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 Not applicable 05 Balancing Foundation SPF 15 Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 4362 First Aid Kit Octinoxate (7.5 g/100mL) + Ammonia (0.045 g/0.3mL) + Avobenzone (1 g/100mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Homosalate (5 g/100mL) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Octisalate (5 g/100mL) + Oxybenzone (6 g/100mL) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL) Kit Ophthalmic; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc. 2018-09-13 Not applicable Abalone Crystaldouble EX Bb Octinoxate (2 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL) + Octocrylene (3 g/100mL) + Titanium dioxide (9.9 g/100mL) Cream Topical C&bcosmetic Co.,ltd. 2017-03-10 Not applicable Abalone Crystaldouble EX Cc Octinoxate (7 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL) + Titanium dioxide (4.694 g/100mL) Cream Topical C&bcosmetic Co.,ltd. 2017-03-10 Not applicable AHC Premium Intense Contour Balm Octinoxate (1.5 g/50mL) + Adenosine (0.02 g/50mL) + Aluminium tristearate (0.04 g/50mL) + Aluminum hydroxide (0.45 g/50mL) + Arbutin (1 g/50mL) + Methicone (20 CST) (1.3 g/50mL) + Talc (2.05 g/50mL) + Titanium dioxide (3.96 g/50mL) + Zinc oxide (0.96 g/50mL) Cream Topical Carver Korea Co.,Ltd. 2014-01-15 2017-11-22 Alphaquin HP Octinoxate (75 mg/1g) + Hydroquinone (40 mg/1g) + Oxybenzone (50 mg/1g) Cream Topical Stratus Pharmaceuticals 1993-01-01 2017-02-01 by Selected Daily Broad Spectrum Sunscreen Octinoxate (3.5 g/50mL) + Octisalate (2.0 g/50mL) Cream Topical Garam Of Nature 2021-07-01 Not applicable Condition and Enhance System Full-size Non-surgical Octinoxate (75 mg/1mL) + Hydroquinone (40 mg/1g) + Hydroquinone (40 mg/1g) + Zinc oxide (90 mg/1mL) Kit Topical OMP, INC. 2007-08-20 Not applicable Condition and Enhance System Travel-size Non-surgical Octinoxate (75 mg/1mL) + Hydroquinone (40 mg/1g) + Hydroquinone (40 mg/1g) + Zinc oxide (90 mg/1mL) Kit Topical OMP, INC. 2007-08-20 Not applicable Condition and Enhance System Travel-size Surgical Octinoxate (75 mg/1mL) + Hydroquinone (40 mg/1g) + Hydroquinone (40 mg/1g) + Zinc oxide (90 mg/1mL) + Zinc oxide (185 mg/1g) Kit Topical OMP, INC. 2007-08-20 Not applicable Conju Princess UV Sun Block Octinoxate (0.075 mL/1mL) + Avobenzone (0.03 mL/1mL) + Enzacamene (0.05 mL/1mL) + Titanium dioxide (0.0249 mL/1mL) + Zinc oxide (0.01 mL/1mL) Cream Topical Conju Inc 2010-12-18 Not applicable
- ATC Codes
- D02BA02 — Octinoxate
- Drug Categories
- Acids, Carbocyclic
- Compounds used in a research, industrial, or household setting
- Drugs that are Mainly Renally Excreted
- Emollients and Protectives
- Household Products
- Protective Agents
- Protectives Against UV-Radiation
- Protectives Against UV-Radiation for Topical Use
- Radiation-Protective Agents
- Sunscreen Agents
- Chemical TaxonomyProvided by Classyfire
- This compound belongs to the class of organic compounds known as cinnamic acid esters. These are compound containing an ester derivative of cinnamic acid.
- Organic compounds
- Super Class
- Phenylpropanoids and polyketides
- Cinnamic acids and derivatives
- Sub Class
- Cinnamic acid esters
- Direct Parent
- Cinnamic acid esters
- Alternative Parents
- Styrenes / Phenoxy compounds / Methoxybenzenes / Anisoles / Fatty acid esters / Alkyl aryl ethers / Enoate esters / Monocarboxylic acids and derivatives / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds show 1 more
- Alkyl aryl ether / Alpha,beta-unsaturated carboxylic ester / Anisole / Aromatic homomonocyclic compound / Benzenoid / Carbonyl group / Carboxylic acid derivative / Carboxylic acid ester / Cinnamic acid ester / Enoate ester / Ether / Fatty acid ester / Fatty acyl / Hydrocarbon derivative / Methoxybenzene / Monocarboxylic acid or derivatives / Monocyclic benzene moiety / Organic oxide / Organic oxygen compound / Organooxygen compound / Phenol ether / Phenoxy compound / Styrene show 13 more
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
- CAS number
- InChI Key
- IUPAC Name
- 2-ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate
- General References
- Monteiro MS, Ozzetti RA, Vergnanini AL, de Brito-Gitirana L, Volpato NM, de Freitas ZM, Ricci-Junior E, dos Santos EP: Evaluation of octyl p-methoxycinnamate included in liposomes and cyclodextrins in anti-solar preparations: preparations, characterizations and in vitro penetration studies. Int J Nanomedicine. 2012;7:3045-58. doi: 10.2147/IJN.S28550. Epub 2012 Jun 20. [Article]
- Mota Ade C, de Freitas ZM, Ricci Junior E, Dellamora-Ortiz GM, Santos-Oliveira R, Ozzetti RA, Vergnanini AL, Ribeiro VL, Silva RS, dos Santos EP: In vivo and in vitro evaluation of octyl methoxycinnamate liposomes. Int J Nanomedicine. 2013;8:4689-701. doi: 10.2147/IJN.S51383. Epub 2013 Dec 10. [Article]
- Schneider S, Deckardt K, Hellwig J, Kuttler K, Mellert W, Schulte S, van Ravenzwaay B: Octyl methoxycinnamate: two generation reproduction toxicity in Wistar rats by dietary administration. Food Chem Toxicol. 2005 Jul;43(7):1083-92. [Article]
- Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, Wulf HC: Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. J Invest Dermatol. 2004 Jul;123(1):57-61. [Article]
- Hayden CG, Cross SE, Anderson C, Saunders NA, Roberts MS: Sunscreen penetration of human skin and related keratinocyte toxicity after topical application. Skin Pharmacol Physiol. 2005 Jul-Aug;18(4):170-4. Epub 2005 May 20. [Article]
- Latha MS, Martis J, Shobha V, Sham Shinde R, Bangera S, Krishnankutty B, Bellary S, Varughese S, Rao P, Naveen Kumar BR: Sunscreening agents: a review. J Clin Aesthet Dermatol. 2013 Jan;6(1):16-26. [Article]
- Duale N, Olsen AK, Christensen T, Butt ST, Brunborg G: Octyl methoxycinnamate modulates gene expression and prevents cyclobutane pyrimidine dimer formation but not oxidative DNA damage in UV-exposed human cell lines. Toxicol Sci. 2010 Apr;114(2):272-84. doi: 10.1093/toxsci/kfq005. Epub 2010 Jan 13. [Article]
- Maipas S, Nicolopoulou-Stamati P: Sun lotion chemicals as endocrine disruptors. Hormones (Athens). 2015 Jan-Mar;14(1):32-46. [Article]
- The Dermatology Review: Octinoxate [Link]
- Download (61 KB)
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Melasma 1 4 Recruiting Treatment Diabetes Complications 1 3 Active Not Recruiting Treatment Acute Promyelocytic Leukemia With PML-RARA 1 3 Completed Treatment Osteoarthritis (OA) 1 2 Completed Supportive Care Advanced Malignant Neoplasm / Dermatologic Complications 1 2 Recruiting Supportive Care CNS Tumor, Childhood / Dermatitis / Pediatrics Cancer 1 2 Recruiting Treatment Acute Promyelocytic Leukemia With PML-RARA 1 2, 3 Recruiting Treatment Actinic Cheilitis 1 1 Completed Basic Science Absorption; Chemicals / Coronavirus Disease 2019 (COVID‑19) / Sunscreening Agents 1 1 Completed Other Systemic Exposure to Sunscreen Ingredients 1
- Not Available
- Not Available
- Dosage Forms
Form Route Strength Stick Topical 50 mg / g Cream Topical 67 mg/1mL Emulsion Topical 5 % w/w Kit Ophthalmic; Respiratory (inhalation); Topical Cream Topical 5 g/100g Stick Topical 7.5 % Cream Topical 0.9 g/30mL Gel Cutaneous Cream Topical 65 mg/1mL Stick Topical 7 % Powder Topical 2.0 % Spray Cutaneous Lotion Topical 0.975 g/15g Lotion Topical 5 % w/w Emulsion Topical 7.5 % w/w Cream Topical 3 g / 100 g Salve Topical Liquid Topical 7 % w/w Lotion Topical 4.5 % Cream Topical 6.3 % w/w Lotion Topical 30 mg / g Gel Topical 25 mg/1g Patch Topical Ointment Topical 5.5 % Spray Topical 10.5 g/150g Ointment Topical Cream Topical 5550 mg/75g Cream Topical 7.5 g/100g Cream Topical 0.6 g/12g Cream Cutaneous Stick Topical 7.5 % w/w Lotion Topical 3 % Cream Topical 3 % Ointment; stick Topical Kit Topical Stick Topical 3.50 % Emulsion Topical 2.23 % Cloth; cream Topical Lotion Topical 4 % Powder Topical Cream Topical 70 mg/1mL Liquid Topical 6.0 % Liquid Topical 3.00 % Cream Topical 15 mL/200mL Powder Topical 6 % w/w Lotion Topical 3.5 % Cream Topical 6 mL/100mL Cream Topical 5.49 g/100g Cream Topical 3 g/50g Cream Topical 6 % Stick Oral Emulsion Topical 75 mg/1mL Lipstick Topical 5 g/100g Stick Topical 306 mg/9g Emulsion Topical 1690 mg/34.48g Cream Topical 1690 mg/34.48g Stick Topical 3.4 % w/w Cream Topical 5 % Cream Topical 2 mg/1mL Lipstick Topical 0.07 g/1g Liquid Topical 3 g/100mL Powder Topical 0.05 g/1g Liquid Topical 6 g/100mL Spray Topical Lotion Topical 75 mg/1mL Paste Topical 75 mg/1mL Powder Topical 5.0 % w/w Powder Topical 5 g/100g Liquid Topical 7.5 % w/w Emulsion Topical 74.9 mg/1mL Lotion Topical 74.9 mg/1mL Emulsion Topical 7.0 % Liquid Topical 2.2 mL/100mL Cream Topical 3.75 mg/50mL Oil Topical 35 mg/1mL Cream Topical 7.5 g/100mL Liquid Topical 7.5 g/100g Cream Topical 7 g/100g Lipstick Topical 0.072 g/1g Liquid Topical 5.0 % Emulsion Topical 4 % Powder Topical 0.06 g/1g Lipstick Topical 0.068 g/1g Lipstick Topical 0.075 g/1g Ointment Topical 6.5 % Liquid Topical 2.2 % Cream Topical 5.6 % Stick Topical 6.5 % w/w Cream Topical 0.6 g/15mL Cream Topical 2 g/50mL Cream Topical 7 % Cream Topical 2 g/40mL Liquid Topical 4 g / 100 g Lotion Topical 6.5 % Powder Topical 7.5 g / 100 g Powder Topical 4 % Powder Topical 7.5 % Emulsion Topical 18.75 mL/250mL Lotion Topical 1.1988 mL/30mL Cream Topical 50 mg/1mL Lipstick Topical 69 mg/1g Stick Topical 68 mg/1g Lipstick Topical 68 mg/1g Cream Topical 10 mg/1mL Cream Topical 28 mg/1mL Cream Topical 50 mg/1g Powder Topical 50 mg/1g Aerosol Topical 50 mg/1mL Emulsion Topical 4.9965 mg/100mg Lipstick Topical 122.5 mg/3.5g Emulsion Topical 30 mg/1mL Emulsion Topical 3 g/100g Liquid; lotion Topical Liquid Topical 2.20 mL/100mL Stick Topical 2 % Liquid Topical 2.23 % Cream Topical 40 mg/1mL Lotion Topical 20 mg/1mL Liquid Topical 50 mg/1mL Emulsion Topical 49.9 mg/1mL Lotion Topical 67 mg/1mL Cream Topical 2 % Stick Cutaneous Cream Topical 3 mL/100mL Lipstick Topical 75 mg/1mL Lipstick Topical 74 mg/1mL Jelly Topical Cream Topical 2.5 % Spray Topical 3 % w/w Lipstick Topical 225 mg/3g Lipstick Topical 525 mg/7g Spray Topical 9.75 mL/130mL Cream Topical Liquid Topical 5 % Liquid Topical 2 % Liquid Topical 4 % Cream Topical 2.25 mL/30mL Cream Topical 4 % Lotion Topical 2.0 % w/w Cream Topical 1.5 g/30g Cream Topical 1.5 mL/30mL Lotion Topical 2275 mg/35mL Oil Topical Stick Topical 4 % w/w Cream Topical 3.75 mL/50mL Cream Topical 75 mg/1mL Liquid Topical 30 mg/1mL Lotion Topical 50 mg/1mL Liquid Topical 75 mg/1mL Powder Topical 75 mg/1g Stick Topical 0.12 g/4g Lotion Topical 1.95 g/30mL Cream Topical 35 mg/1mL Cream Topical 3.5 g/100g Lotion Topical 35 mg/1mL Lotion Topical 3.5 g/100mL Lotion Topical 2.1 g/30mL Liquid Topical 0.07 g/1mL Liquid Topical 0.045 g/1g Cream Topical 1.35 g/30g Lotion / shampoo Topical Suspension Topical Ointment Topical 1.0 % Cream Topical 7.5 g / 100 g Cream Topical 6 mL/30mL Cream Topical 1.8 g/30mL Liquid Topical 70 mg/1mL Cream Topical 49 mg/1g Cream Topical 60 mg/1mL Cream Topical 60 mg/100mL Emulsion Topical 5.0 % w/w Cream Topical 2.5 % w/w Liquid Topical 3.5 % w/w Liquid Topical 7 mL/100mL Liquid Topical 7 % Liquid Topical 7.5 % Solution Topical Cream Topical 0.525 g/7mL Lotion Topical 7.5 % Cream Topical 7.5 % w/w Lipstick Topical Lotion Topical 0.9 g/30g Lotion Topical 45 mg/1mL Powder Topical 40 mg/1g Ointment Topical 5 % Powder Topical 0.42 g/14g Cream Topical 10 g/100g Liquid Topical 7.5 mL/100mL Lipstick Topical 2.2 mL/100mL Liquid Topical 3 % Liquid Topical Stick Topical 222 mg/3g Stick Topical 10 mg/1g Stick Topical 30 mg/1g Lotion Topical 2 g/100mL Cream Topical 7.5 g/30g Emulsion Topical 2.25 g/30g Emulsion Topical Emulsion Topical 1.5 g/30g Kit; lotion Topical Cream Topical 1.5 g/100g Lotion Topical 0.05 g/1mL Lotion Topical 7 % w/w Liquid Not applicable 1 L/1L Cream Topical 3.5 g/50mL Stick Topical 3.5 % w/w Oil Topical 16.8 mg/1mL Oil Topical 19.3 mg/1mL Spray Topical 19.8 mg/1mL Oil Topical 2 g/100g Lotion Cutaneous Cream Topical 11.25 mL/150mL Lotion Topical 5.0 % Cream Topical 3.75 g/50mL Lotion Topical 6 % Cream Topical 7.5 % Stick Topical 4.9 % w/w Lipstick Topical 3.5 g/100g Cream; kit Topical Powder Cutaneous Cream Topical 7.5 mL/100mL Stick Topical 5 % Powder Topical 2 % Cream Topical 1.3 g/30mL Liquid Topical 4 g/100mL Paste Topical 7.5 g/100g Lipstick Topical 7.5 g/100g Lipstick Topical 0.28 g/4g Cream Topical 7.0 % Lotion Topical 2.25 g/30mL Suspension Topical 7.5 % Gel Topical 3 g/100mL Cream Topical 4 g/100mL Suspension Topical 4 % Lipstick Topical 20 mg/1mL Cream Topical 6.0 % Emulsion Topical 7.5 % Lotion Topical 7.4 % Cream Topical 7.4 % Cream Topical 2036 mg/30mL Cream Topical 1832 mg/30mL Stick Topical 196 mg/4g Emulsion Topical 4.5 % Lipstick Topical 196 mg/4g Stick Topical 4.996 % Stick Topical 4 % Lotion Topical 1.125 mL/15mL Lotion Topical 2.25 mL/30mL Liquid Topical 60 mg/1mL Liquid Topical 6 % Lotion Topical 60 mg/1mL Aerosol Topical Stick Topical 7.0 % Lipstick Topical 75 mg/1g Cream Topical 4.5 % Spray, suspension Topical Lotion Topical 2 % w/w Spray Oral Paste Topical Emulsion Topical 2 % Liquid Topical 2.5 % Gel Topical 3.5 mL/100mL Paste Topical 67.4 mg/1g Lipstick Topical 67.4 mg/1g Liquid Topical 1.95 g/30mL Sponge Topical Soap Topical Stick Topical 3.5 % Stick Topical Lotion Topical 2.5 % Lotion Topical 5.5 % Liquid; spray Topical Liquid Topical 1 % Spray Topical 5 g/100g Cloth Topical Spray Topical 16.7 mg/1mL Gel Topical 0.075 g/1g Stick Topical 3 % Lotion; spray Topical Lotion Topical 6 g/100mL Emulsion Topical 3 % Emulsion Topical 5 % Lotion Topical 3 % w/w Cream Topical 30 mg/1mL Cream Topical 3.0 % Lotion Topical 7.50 % Cream Topical 4 % w/w Liquid Topical 25 mg/1mL Powder Topical 25 mg/1mL Lotion Topical Cream Topical 3 g/100mL Cream, augmented Topical Gel Topical Cream Topical 0.36 g/7.2g Powder Topical 5 % Powder Topical 5.2 % Cream Topical 68 mg/1mL Cream Topical 2.0 mL/100mL Lipstick Topical 7.0 g/100g Powder Topical 7.5 % w/w Cream Topical 6.3 g/100g Lotion Topical 5 g/100g Lotion Topical 7 g/100g Liquid Topical 5 g / 100 g Lipstick Topical 210 mg/3g Stick Topical 7.0 % w/w Lipstick Topical 0.225 g/3g Cream Topical 4.995 % Lotion Topical 4.995 % Aerosol, foam Topical Aerosol, spray Topical Liquid Topical 0.075 g/1mL Liquid Topical 0.075 mL/1mL Lotion Topical 2 % Lotion Topical 1.25 % Cream; liquid Topical Liquid Topical 5.4 mL/100mL Lotion Topical 6.0 % Cream Topical 4.0 % Lotion Topical 5 % Emulsion Topical 50 mg/1mL Spray Topical 3 g/100g Liquid Topical 40 mg/1mL Lipstick Topical 40 mg/1g Lotion Topical 3 g/100g Lotion Topical 65 mg/1mL Lotion Topical 30 mg/1mL Lotion Topical 70 mg/1mL Lipstick Topical 20 mg/1g Powder Topical 60 mg/1g Cream Topical 74.9 mg/1mL Lotion Topical 68 mg/1mL Lotion Topical 40 mg/1mL
- Not Available
- Not Available
- Experimental Properties
Property Value Source melting point (°C) -25°C MSDS boiling point (°C) 185-195°C at 1mbar MSDS water solubility <0.1 g/100 mL at 27°C A19210 logP 5.8 MSDS
- Predicted Properties
Property Value Source Water Solubility 0.000452 mg/mL ALOGPS logP 5.62 ALOGPS logP 5.38 ChemAxon logS -5.8 ALOGPS pKa (Strongest Basic) -4.8 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 2 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 35.53 Å2 ChemAxon Rotatable Bond Count 10 ChemAxon Refractivity 86.44 m3·mol-1 ChemAxon Polarizability 34.84 Å3 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five No ChemAxon Ghose Filter Yes ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon
- Predicted ADMET Features
- Not Available
- Mass Spec (NIST)
- Not Available
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at November 30, 2015 19:10 / Updated at October 26, 2021 21:40