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Sulpiride
go.drugbank.com/drugs/DB00391ApprovedWithdrawn[A229538] Clinical studies show a greater effect on treating the negative symptoms of schizophrenia rather than positive symptoms at low doses, though the effects are more equal at higher doses. … [A229683] Sulpiride is not approved by the FDA, Health Canada, or the EMA; though it is approved in individual European countries.[L24679]
Categories: MATE 2 SubstratesSynonyms: N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide, 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamideMethotrexate
go.drugbank.com/drugs/DB00563ApprovedInvestigational[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients … [L7180] Methotrexate was granted FDA approval on 7 December 1953.[L7198]
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesSynonyms: 4-amino-N(10)-methylpteroylglutamic acid, 4-amino-10-methylfolic acidVenlafaxine
go.drugbank.com/drugs/DB00285ApprovedInvestigationalIt was also considered a second-line treatment for obsessive-compulsive disorder (OCD). … [A252065] Venlafaxine has been used as a first-line treatment for MDD, GAD, social anxiety disorder, and panic disorder in Canada for many years.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: VENLIFT ER 150 MG CAPSULE, Efectin ER 150 mg Hartkapseln, retardiertBismuth subcitrate potassium
go.drugbank.com/drugs/DB09275ApprovedInvestigationalA bismuth compound used for peptic ulcer and gastro-oesophageal reflux disease (GORD).
Mixtures: KATACOLD 120 MG + 3.75 MG+ l MG /5 ML PEDIYATRIK ŞURUP, 100 ML, Pylera 140 mg/125 mg/125 mg HartkapselnProducts: NOTUSS 50 MG SR TABLET, 20 ADET, KREVAL SR 50 MG FİLM KAPLI TABLET , 20 ADETTrimebutine
go.drugbank.com/drugs/DB09089ApprovedInvestigationalTrimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects. … Trimebutine is not a FDA-approved drug, but it is available in Canada and several other international countries.
Mixtures: RECBUTIN 120 MG/10 MG SUPOZITUVAR, 10 ADET, LIBERTRIM® SII 100 MGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesBrivaracetam
go.drugbank.com/drugs/DB05541ApprovedInvestigationalBrivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam [A19184]. … It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 [L760].
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesProducts: BRIVIACT 10 MG FILM KAPLI TABLET ,14 FILM KAPLI TABLET, BRIVIACT 50 MG FILM KAPLI TABLET ,14 FILM KAPLI TABLETItraconazole
go.drugbank.com/drugs/DB01167ApprovedInvestigationalWhile the intravenous formulation of the drug was formerly available, it was discontinued in the US in 2007.[A263232] … [L50051] Itraconazole was first approved in the US in 1992 [L50056] and is available orally.
Mixtures: ITRACONAZOL 33.3 MG + SECNIDAZOL 166.66 MG CÁPSULA, Ciclopirox 3% / Itraconazole 5% / Urea 20%Categories: 14-alpha Demethylase Inhibitors, Cytochrome P-450 SubstratesHaloperidol
go.drugbank.com/drugs/DB00502ApprovedInvestigational[A180616] While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain,[A27477] it exerts its antipsychotic effect through its strong antagonism of the dopamine receptor … [F4645] It is also used off-label for the management of chorea associated with Huntington's disease and for the treatment of intractable hiccups as it is a potent antiemetic.
Categories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT2 Receptor AntagonistsSynonyms: 4'-fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-oneGinkgo biloba
go.drugbank.com/drugs/DB01381ApprovedInvestigationalNutraceutical[A232404] EGb761 contains 6% terpene lactones and 24% flavonoid glycosides.[A232379] Flavonoids include quercetin, rutin, kaempferol, and isorhamnetin. … [L32789] _Ginkgo biloba_ is an herbal plant that is now cultivated worldwide. It is originally native to China, and _ginkgo biloba_ extract has been used in traditional Chinese medicine for centuries.
Mixtures: MEGINGO 20/50 MG EFERVESAN TABLET, 100 ADET, MEGINGO 10/50 MG EFERVESAN TABLET, 100 ADETCategories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP1A2 InhibitorsAbemaciclib
go.drugbank.com/drugs/DB12001ApprovedInvestigationalIt is either given alone in patients who has undergone endocrine therapy and chemotherapy after the metastasis of cancer, or in combination with [DB00947]. … Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity
Categories: MATE 2 Inhibitors, Heterocyclic Compounds, 2-RingProducts: YULAREB 50 MG FİLM KAPLI TABLET, 28 ADET, YULAREB 100 MG FİLM KAPLI TABLET, 28 ADET