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Benznidazole
go.drugbank.com/drugs/DB11989ApprovedInvestigational[L939] It is the first treatment made available in the United States for Chagas disease. … Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: ABALEA ®100 MGNateglinide
go.drugbank.com/drugs/DB00731ApprovedApproximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. … Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAuranofin
go.drugbank.com/drugs/DB00995ApprovedInvestigationalAuranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. … Heme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties.
Synonyms: 2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold, (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetateThiethylperazine
go.drugbank.com/drugs/DB00372ApprovedInvestigationalWithdrawnA dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins.
Synonyms: 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazineCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 3-RingRiluzole
go.drugbank.com/drugs/DB00740ApprovedInvestigationalRiluzole is marketed as Rilutek by Sanofi. … A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingInternational brands: Xie Yi LiCevimeline
go.drugbank.com/drugs/DB00185ApprovedCevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. … It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: 2-Methyspiro(1,3-oxathiolane-5,3)quinuclidineCarboprost tromethamine
go.drugbank.com/drugs/DB00429ApprovedInvestigationalA nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy.
Categories: Prostaglandins F, SyntheticSynonyms: 15(S)-15-methyl-PGF2α tromethamine salt, 15(S)-15-methylprostaglandin F2α tromethamineCarbon monoxide
go.drugbank.com/drugs/DB11588ApprovedInvestigationalCarbon monoxide (CO) is a colorless, odorless, and tasteless gas that has a slightly lower density than air. … Carbon monoxide (CO), is a ubiquitous environmental product of organic combustion, which is also formed endogenously in the human body, as the byproduct of heme metabolism [A32758].
Synonyms: carbon(II) oxideMinaprine
go.drugbank.com/drugs/DB00805ApprovedMinaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. … Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.
Synonyms: 4-(2-((4-Methyl-6-phenyl-3-pyridazinyl)amino)ethyl)morpholine, N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamineCategories: Cytochrome P-450 Substrates, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesSacrosidase
go.drugbank.com/drugs/DB06760ApprovedSacrosidase is a liquid enzyme preparation from S.cerevisiae used for the treatment of congenital sucrose-isomaltase deficiency (CSID). … Treatment options for these patients are limited and usually consists of a lifelong sucrose-free diet; therefore, sacrosidase offers a potential alternative for symptom relief.