Thiethylperazine is a drug used for the treatment of nausea and vomiting. A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins.
- Mechanism
- Curator reviewed
Thiethylperazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Thiethylperazine's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Thiethylperazine does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Antagonism at muscarinic receptors, H1-receptors, and alpha(1)-receptors also occurs with thiethylperazine.
- Primary indication
- For the treatment or relief of nausea and vomiting.Curator reviewed · 4 structured indications
- Formula / weight
- C22H29N3S2 · 399.616 g/mol (avg)
- First approval
- United States, 2006
- Also known as
- Norzine
- Code names
- GS 95 · NSC 130044
Resolves to
XCTYLCDETUVOIP-UHFFFAOYSA-NSMILESCCSC1=CC2=C(SC3=CC=CC=C3N2CCCN2CCN(C)CC2)C=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Thiethylperazine, and which of those have an active Phase 3 trial?
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