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Levoleucovorin
go.drugbank.com/drugs/DB11596ApprovedInvestigationalCommercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. … This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects of methotrexate therapy.
Categories: Heterocyclic Compounds, 2-Ring, Vitamin B ComplexSynonyms: N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, L-Leucovorin4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID
go.drugbank.com/drugs/DB07827ExperimentalSynonyms: 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACIDClorazepic acid
go.drugbank.com/drugs/DB00628ApprovedIllicitSimilar to other benzodiazepines, the active metabolite of clorazepate enhances the binding of gamma-aminobutyric acid (GABA) to the GABA type A (GABA-A) receptor, which promotes channel opening and neuronal … Clorazepic acid (clorazepate) is a water-soluble benzodiazepine with muscle-relaxant and anticonvulsant actions effective in the treatment of anxiety.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesSynonyms: 7-chloro-2,3-dihydro-2,2-dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acidSegesterone acetate
go.drugbank.com/drugs/DB14583ApprovedIn clinical trials, Annovera™ achieved a 97.3% success in pregnancy prevention [L4246]. Annovera™ is administered as a vaginal ring that is in place for 21 days and removed for 7 days each cycle. … Segesterone acetate is a steroidal progestin or synthetic progesterone and a 19-norprogesterone derivative with no CH3 group radical in position 6 [A37048].
Synonyms: 16-Methylene-17-alpha-acetoxy-19-nor-4-pregnene-3,20-dione, 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesKanamycin
go.drugbank.com/drugs/DB01172ApprovedInvestigationalVet approvedWithdrawnKanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections.
Synonyms: 4,6-diamino-2-hydroxy-1,3-cyclohexane 3,6'diamino-3,6'-dideoxydi-α-D-glucoside, 4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-D-glucopyranosideInternational brands: Kancin-LD-Leucine
go.drugbank.com/drugs/DB01746ExperimentalAn essential branched-chain amino acid important for hemoglobin formation. [PubChem]
Synonyms: D-2-Amino-4-methylvaleric acid, (2R)-2-amino-4-methylpentanoic acidPittsburgh Compound B
go.drugbank.com/drugs/DB15161InvestigationalPittsburgh Compound B is under investigation in clinical trial NCT01723553 (Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD).
Synonyms: 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole, (N-methyl-(11C))2-(4'-methylaminophenyl)-6-hydroxybenzothiazoleCategories: Heterocyclic Compounds, 1-RingDimethylthiambutene
go.drugbank.com/drugs/DB01444ExperimentalIllicitDimethylthiambutene (N,N-Dimethyl-1-methyl-3,3-di-2-thienylallylamine, Dimethibutin, Ohton) is an opioid analgesic drug. … It is now under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse potential, although little more information is available.
Synonyms: N,N-dimethyl-4,4-di(2-thienyl)-3-buten-2-amine, 3-dimethylamino-1,1-bis(2-thienyl)-1-buteneP1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate
go.drugbank.com/drugs/DB03845ExperimentalSynonyms: P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate(3S)-N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
go.drugbank.com/drugs/DB07192ExperimentalSynonyms: (3S)-N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE