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Displaying results 3551 - 3560 of 9322 in total
  1. Drug

    Carmofur

    go.drugbank.com/drugs/DB09010
    ApprovedWithdrawn

    Carmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.

  2. Drug

    Lyme disease vaccine (recombinant OspA)

    go.drugbank.com/drugs/DB00045
    ApprovedWithdrawn

    Lipoprotein OspA is a single polypeptide chain of 257 amino acids with lipids covalently bonded to the N terminus. It is conjugated with alum (aluminum hydroxide) as an adjuvant.

  3. Drug

    Ornithine

    go.drugbank.com/drugs/DB00129
    ApprovedInvestigationalNutraceutical

    Produced during the urea cycle, ornithine is an amino acid produced from the splitting off of urea from arginine. … L-Ornithine allows for the disposal of excess nitrogen and acts as a precursor of citrulline and arginine.

    Mixtures: AMINOPLASMAL-5% E INFUSION, AMINOPLASMAL-10% E INFUSIONProducts: HEPA-MERZ CONCENTRADO DE INFUSIÓN
  4. Drug

    Rosin

    go.drugbank.com/drugs/DB11165
    Approved

    It is prepared from heating fresh liquid resin to vaporize the volatile liquid terpene components. … Rosin has shown to mediate antibacterial actions on Gram-positive bacterial species [A27267].

  5. Drug

    Brecanavir

    go.drugbank.com/drugs/DB04887
    Investigational

    In December of 2006 GSK announced a decision to discontinue the development of brecanavir for the treatment of HIV. The decision was based on issues regarding the formulation of the drug. … In July 2006, Vertex indicated that it expected GSK to initiate phase III trials of the drug in 2007.

  6. Drug

    Lumefantrine co-artemether

    go.drugbank.com/drugs/DB13085
    ApprovedInvestigationalWithdrawn

    The exact mechanism of action of lumefantrine is not well defined, but it is thought to inhibit -hematin formation, an important detoxification pathway for the parasite. … falciparum malaria that is resistant to other antimalarials.

  7. Drug

    Clorgiline

    go.drugbank.com/drugs/DB04017
    Experimental

    An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
  8. Drug

    Lauric acid

    go.drugbank.com/drugs/DB03017
    Approved

    Lauric acid is a solid at room temperature but melts easily in boiling water, so liquid lauric acid can be treated with various solutes and used to determine their molecular masses. … Lauric acid is an inexpensive, non-toxic and safe to handle compound often used in laboratory investigations of melting-point depression.

  9. Drug

    Atractylodes japonica root oil

    go.drugbank.com/drugs/DB11270
    ApprovedWithdrawn

    Atractylodes japonica root oil is obtained from the roots of Atractylodes japonica, which is a herb native to eastern Asia. … Atractylodes japonica is reported to have anti-inflammatory and antinociceptive effects [A27223].

  10. Drug

    Doxofylline

    go.drugbank.com/drugs/DB09273
    Investigational

    The anti-asthmatic effects of doxophylline are mediated by other mechanisms, primarily through inhibiting the activities of the phosphodiesterase (PDE) enzyme. … Decreased affinity for adenosine receptors may account for the better safety profile of doxofylline compared to theophylline [L1169].