Search

Displaying results 3721 - 3730 of 10000 in total
  1. Drug

    Drotrecogin alfa

    go.drugbank.com/drugs/DB00055
    ApprovedWithdrawn

    Drotrecogin alfa was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis. … It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond.

    Categories: Recombinant Activated Protein CSynonyms: Activated protein C, Recombinant human activated protein C (rH-APC)
  2. Drug

    Chloral hydrate

    go.drugbank.com/drugs/DB01563
    ApprovedIllicitInvestigationalVet approved

    The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. … A hypnotic and sedative used in the treatment of insomnia.

    Products: PMS-CHLORAL HYDRATE SYRUP 500 mg/5 ml, HIDRATO DE CLORAL 10%SOLUCION ORAL(GOTAS)
  3. Drug

    Prenylamine

    go.drugbank.com/drugs/DB04825
    ApprovedWithdrawn

    Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.

    Categories: Vasodilators Used in Cardiac Diseases, Cytochrome P-450 SubstratesSynonyms: N-(1-Methyl-2-phenylethyl)-gamma-phenylbenzenepropanamine, N-(3,3-Diphenylpropyl)-alpha-methylphenaethylamin
  4. Drug

    Besifloxacin

    go.drugbank.com/drugs/DB06771
    Approved

    Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis. FDA approved on May 28, 2009.

    Categories: Topoisomerase II Inhibitors, 4-QuinolonesProducts: BESIVANCE % 0,6 OFTALMIK SÜSPANSIYON, 5 ML
  5. Drug

    Crovalimab

    go.drugbank.com/drugs/DB16128
    ApprovedInvestigational

    [A263958] It soon gained its approval in Japan in the next month,[A263958] and in the USA in June of the same year. … Crovalimab is a humanized monoclonal antibody and complement C5 inhibitor.[L50908] It consists of two heavy chains (451 amino acid residues each) and two light chains (217 amino acid residues each).

    Synonyms: IGHJ4*01 (100%)) (9.8.15) (1-123)-HOMO SAPIENS IGHG1*, IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS C5 (COMPLEMENT 5)), MONOCLONAL ANTIBODYGAMMA1 HEAVY CHAIN (1-451) (VH (VICUGNA PACOS IGHV3S1*01 (70.4%)/HOMO SAPIENS IGHV3-66*01 (69.4%)-(IGHD)-HOMO SAPIENS
  6. Drug

    Dextroamphetamine

    go.drugbank.com/drugs/DB01576
    ApprovedIllicitInvestigational

    Dextroamphetamine is the dextrorotatory enantiomer of amphetamine[A2505]. Dextroamphetamine was approved by the FDA in 2001 for the treatment of attention deficit hyperactivity disorder.[L6010,L52145]

    Mixtures: Mixed Salts of a Single-Entity Amphetamine Product, Mixed Salts of a Single-Entity Amphetamine ProductCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates
  7. Drug

    Isoeugenol

    go.drugbank.com/drugs/DB14188
    Approved

    Isoeugenol is a commonly used fragrance added to many commercially available products, and occurs naturally in the essential oils of plants such as ylang-ylang. … It is also a significant dermatologic sensitizer and allergen, and as a result has been restricted to 200 p.p.m. since 1998 according to guidelines issued by the fragrance industry [A34278].

    Synonyms: 2-methoxy-4-(prop-1-en-1-yl)phenol, 1-Hydroxy-2-methoxy-4-propen-1-ylbenzene
  8. Drug

    Isavuconazole

    go.drugbank.com/drugs/DB11633
    ApprovedInvestigational

    It is proposed that the intravenous and oral dosing can be used interchangeably [L1482], without the need for a repeat loading dose when transitioning from an IV to an oral formulation [A32026]. … Resistance to isavuconazole has been associated with the mutation in the target gene CYP51 [FDA Label].

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP2B6 Inducers
  9. Drug

    Exisulind

    go.drugbank.com/drugs/DB06246
    Investigational

    Synonyms: 5-Fluoro-2-methyl-1-((Z)-p-(methylsulfonyl)benzylidene)indene-3-acetic acid, cis-5-Fluoro-2-methyl-1-(p-methylsulfonylbenzylidenyl)indene-3-acetic acidCategories: Compounds used in a research, industrial, or household setting
  10. Drug

    Cocaine

    go.drugbank.com/drugs/DB00907
    ApprovedIllicitInvestigational

    It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. … It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester, methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate