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Exemestane
go.drugbank.com/drugs/DB00990ApprovedInvestigationalExemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal … It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 6-methyleneandrosta-1,4-diene-3,17-dioneQuinapril
go.drugbank.com/drugs/DB00881ApprovedInvestigational[A184844] Quinapril was granted FDA approval on 19 November 1991.[L8420] A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.[L8423] … [L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.
Mixtures: ACCUZIDE FORT 20 MG/25 MG FILM KAPLI TABLET, 30 ADET, Quinapril and Hydrochlorothiazide 20/25Categories: Heterocyclic Compounds, 2-Ring, Agents Acting on the Renin-Angiotensin SystemZidovudine
go.drugbank.com/drugs/DB00495ApprovedInvestigationalA dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. … The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription.
Mixtures: ABACAVIR .LAMIVUDINA +ZIDOVUDINATABLETAS 750 MG, ยาเม็ด จีพีโอ-เวียร์ แซด 250Categories: Antivirals used in combination for the treatment of HIV infections, Cytochrome P-450 SubstratesLetrozole
go.drugbank.com/drugs/DB01006ApprovedInvestigational[A190546] Letrozole was granted FDA approval on 25 July 1997.[L11623] … Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: LETROZOL SUN 2.5 MG, LETARA® 2.5 MG TABLETASVasopressin
go.drugbank.com/drugs/DB00067ApprovedInvestigationalthrough V<sub>1</sub> and V<sub>2</sub> cellular receptors. … Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation
Products: VASOPRESSIN INJECTION USP 20 u/ml, VASOPRESINA INYECTABLE 20 U/ML USPFinerenone
go.drugbank.com/drugs/DB16165ApprovedInvestigational[A236544,L34739] Finerenone was granted FDA approval on 9 July 2021,[L34739] followed by the EMA approval on 11 March 2022.[L41449] … Finerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: KERENDİA 20 MG FİLM KAPLI TABLET, 28 ADET, KERENDİA 20 MG FİLM KAPLI TABLET, 98 ADETRiboflavin
go.drugbank.com/drugs/DB00140ApprovedInvestigationalNutraceuticalVet approvedIt occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. … Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast.
Synonyms: 1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol, Vitamin GMixtures: NEUVITAN 50 MG/ 5 ML KAPLI TABLET, 50 ADET, NEUVITAN 50 MG/ 5 ML KAPLI TABLET, 30 ADETClindamycin
go.drugbank.com/drugs/DB01190ApprovedInvestigationalVet approvedClindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. … The name lincomycin is derived from Lincoln, Nebraska, where it was first isolated from _Streptomyces lincolnensis_ found in a soil sample.[A190621]
Synonyms: Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside, 7(S)-Chloro-7-deoxylincomycinInternational brands: Dalacin C, Dalacin T Topical SolutionIsatuximab
go.drugbank.com/drugs/DB14811ApprovedInvestigational[L12099] It is a cytolytic antibody targeted against CD38, a glycoprotein found on the surface of some immune cells that is highly expressed by malignant plasma cells in multiple myeloma. … Following three consecutive years on the yearly "Antibodies to watch" list published in "mAb", a peer-reviewed scientific journal dedicated to antibody research,[A38676,A191826,A191829] isatuximab was
Products: SARCLİSA 500 MG/25 ML IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET, SARCLİSA 100 MG/5 ML IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADETMesalazine
go.drugbank.com/drugs/DB00244ApprovedInvestigationalAlthough demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent … An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease [A174022].
Synonyms: 5-ASA, 5-aminosalicylic acidProducts: 5-asa, Teva-5 Asa