Search

Displaying results 3921 - 3930 of 10000 in total
  1. Drug

    Peginterferon alfa-2b

    go.drugbank.com/drugs/DB00022
    ApprovedInvestigational

    When combined together, Peginterferon alfa-2b and [Ribavirin] have been shown to achieve a SVR between 41% for genotype 1 and 75% for genotypes 2-6 after 48 weeks of treatment. … HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients [L852].

    Categories: Compounds used in a research, industrial, or household setting, Hepatitis CSynonyms: PEG-IFN-α-2b, Pegylated Interferon α-2b
  2. Drug

    Stanolone

    go.drugbank.com/drugs/DB02901
    IllicitInvestigational

    A potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. … Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid.

    Categories: 5-Androstanon (3) Derivatives, P-glycoprotein substratesSynonyms: 4-Dihydrotestosterone, 17beta-Hydroxyandrostan-3-one
  3. Drug

    Vardenafil

    go.drugbank.com/drugs/DB00862
    Approved

    Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction. … [A258313] The use of vardenafil as a monotherapy for the treatment of pulmonary arterial hypertension has also been evaluated.[A258308]

    Categories: Drugs Used in Erectile Dysfunction, P-glycoprotein inhibitorsProducts: VAREKSİL 5 MG FİLM KAPLI TABLET, 4 ADET, LEVITRA 5 MG FILM KAPLI TABLET, 4 ADET
  4. Drug

    Alirocumab

    go.drugbank.com/drugs/DB09302
    ApprovedInvestigational

    Alirocumab is a biopharmaceutical that obtained FDA approval in July 2015 as a second line treatment for high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of … PCSK9 inhibition facilitates more LDL-C clearance from the blood.

    Categories: Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) InhibitorsProducts: PRALUENT 150 MG/ML SC ENJEKSIYONLUK ÇÖZELTI IÇEREN KULLANIMA HAZIR KALEM,6 ADET, PRALUENT SOLUTION FOR INJECTION IN A PRE-FILLED PEN 150 MG/ML
  5. Drug

    Pitavastatin

    go.drugbank.com/drugs/DB08860
    ApprovedInvestigational

    More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid. … were found in clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels.

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: Trolise 4 mg Filmtabletten, ALIPZA 4 MG FILM KAPLI TABLET, 90 ADET
  6. Drug

    Zalunfiban

    go.drugbank.com/drugs/DB18766
    Investigational

    Synonyms: 2-amino-n-(4-(5-oxo-7-(piperazin-1-yl)-5h-(1,3,4)thiadiazolo(3,2-a)pyrimidin-2-yl)pyridin-2-yl)acetamide, Acetamide, 2-amino-n-(5-(5-oxo-7-(1-piperazinyl)-5h-1,3,4-thiadiazolo(3,2- a)pyrimidin-2-yl)-3-pyridinyl)-
  7. Target

    2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

    go.drugbank.com/bio_entities/BE0001488
    TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

    Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

    Polypeptides: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseSynonyms: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
  8. Drug

    Reboxetine

    go.drugbank.com/drugs/DB00234
    ApprovedInvestigationalWithdrawn

    Reboxetine has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine. … Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: EDRONAX 4 MG TABLET, 60 ADET, Edronax 4 mg - Tabletten
  9. Drug

    Erythropoietin

    go.drugbank.com/drugs/DB00016
    ApprovedInvestigational

    Erythropoietin (EPO) is a growth factor produced in the kidneys that stimulates the production of red blood cells. … Epoetin alfa is a 165-amino acid erythropoiesis-stimulating glycoprotein produced in cell culture using recombinant DNA technology and is used for the treatment of patients with anemia associated with

    Synonyms: 1-165-Erythropoietin (human clone λHEPOFL13 protein moiety), glycoform αProducts: Binocrit 40, 000 IU/1 ml solution for injection in a pre-filled syringe, EPREX 10000 IU/ML SIRINGA, 6 ADET
  10. Drug

    Ripertamab

    go.drugbank.com/drugs/DB16314
    Investigational

    Ripertamab is under investigation in clinical trial NCT02772822 (A Study Comparing the Efficiency and Safety of S-chop(cyclophosphamide, Hydroxydaunomycin, Oncovin, and Prednisone) Versus R-CHOP in Untreated

    Synonyms: Immunoglobulin g1-kappa, anti-(homo sapiens ms4a1 (membrane-spanning 4-domains subfamily a member 1, cd20)), chimeric monoclonal antibody, Immunoglobulin igg1, anti-(human cd20 antigen) (human-mus musculus monoclonal disulfide sct400 .gamma.1-chain), disulfide with human-mus musculus monoclonal sct400 .kappa.-chain, dimer