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Displaying results 31 - 40 of 14186 in total
  1. Drug

    Garadacimab

    go.drugbank.com/drugs/DB15629
    Approved

    Garadacimab is a fully human monoclonal antibody targeted against activated factor XII. … [L53283,A273998] Garadacimab received its first approval in Australia and the UK in January 2025, and has since been approved in a number of other jurisdictions, including the EU and Japan.

    Synonyms: Immunoglobulin G4, anti-(human blood-coagulation factor viia) (human monoclonal CSL312 gamma4-chain), disulfide with human monoclonal CSL312 lambda-chain, dimerCategories: Blood and Blood Forming Organs, Amino Acids, Peptides, and Proteins
  2. Drug

    Reteplase

    go.drugbank.com/drugs/DB00015
    ApprovedInvestigationalWithdrawn

    Three domains are deleted from retavase - kringle-1, finger, and epidermal growth factor (EGF). … Retavase contains 355 of the 527 amino acids of native human tPA (amino acids 1-3 and 176-527), and retains the activity-related kringle-2 and serine protease domains of human tPA.

    Categories: Biological Factors, Enzymes and CoenzymesSynonyms: Human t-PA (residues 1-3 and 176-527), Reteplase,recombinant
  3. Drug

    Apadamtase alfa

    go.drugbank.com/drugs/DB15164
    ApprovedInvestigational

    for cleaving large von Willebrand factor multimers and preventing the formation of microthrombi - this deficiency in ADAMTS13 is responsible for the microangiopathic complications associated with cTTP … [A262071] Apadamtase alfa, sold under the brand name Adzynma (ADAMTS13, recombinant-krhn), was approved by the FDA in November 2023 for use as an enzyme replacement therapy in patients with cTTP.

    Categories: Recombinant Proteins, von Willebrand FactorSynonyms: Recombinant human adamts13, Recombinant disintegrin and metalloprotease with thrombospondin type 1 motifs
  4. Drug

    Drotrecogin alfa

    go.drugbank.com/drugs/DB00055
    ApprovedWithdrawn

    Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. … It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond.

    Categories: Blood Coagulation Factor Inhibitors, Recombinant Activated Protein CSynonyms: Blood coagulation factor XIV (human), Recombinant human activated protein C (rH-APC)
  5. Drug

    Isopropyl myristate

    go.drugbank.com/drugs/DB13966
    Approved

    Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. … Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer.

    Synonyms: Isopropyl myristate, Isopropyl tetradecanoateCategories: Scabicides and Pediculicides
  6. Drug

    Omidenepag isopropyl

    go.drugbank.com/drugs/DB15071
    Approved

    [A253253] In 2018, omidenepag isopropyl was approved in Japan for the treatment of glaucoma and ocular hypertension.[A253268] In September 2022, the FDA approved the use of omidenepag isopropyl. … Omidenepag isopropyl is a topical ocular hypotensive agent used to reduce intraocular pressure (IOP) in patients with glaucoma and ocular hypertension.

    Synonyms: Omidenepag isopropyl, isopropyl N-(6-(((4-(1H-pyrazol-1-yl)benzyl)(3-pyridinylsulfonyl)amino)methyl)-2-pyridinyl)glycinate
  7. Drug

    Cinnamyl alcohol

    go.drugbank.com/drugs/DB14186
    Approved

    Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. … Due to the low levels found in cinnamon, cinnamyl alcohol is usually supplied as [DB14184] within commercial products.

    Synonyms: Cinnamyl alcohol, (E)-cinnamyl alcoholCategories: Alcohols
  8. Drug

    Propyl alcohol

    go.drugbank.com/drugs/DB03175
    Approved

    A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.

    Synonyms: N-propyl alcoholMixtures: Alsoft Liquid Hand Sanitizer (Ethanol 66.5% w/w and n-Propyl Alcohol 10% w/w), ZHUSHI Hand sanitizer gel
  9. Drug

    Dichlorobenzyl alcohol

    go.drugbank.com/drugs/DB13269
    Approved

    Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections. … [A33047] Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical.

    Mixtures: STREPSILS HONEY AND LEMON, Difflam plus ANAESTHETIC Sore Throat Lozenges (Sugar Free) Menthol and Eucalyptus FlavourCategories: dichlorobenzyl alcohol, Alcohols
  10. Drug

    Thrombin

    go.drugbank.com/drugs/DB11300
    ApprovedInvestigational

    Also known as coagulation factor II, thrombin is a serine protease that plays a physiological role in regulating hemostasis and maintaining blood coagulation. … A variety of human thrombin and recombinant thrombin (ie. thrombin alfa) products are available as alternatives to using bovine thrombin.

    Synonyms: coagulation factor IIMixtures: TACHOSİL 5,5 MG/CM2 İNSAN FİBRİNOJENİ VE 2.0 IU/CM2 İNSAN TROMBİNİ İLAÇLI SÜNGER, Tisseel Lyo - Pulver und Lösungsmittel für einen Gewebekleber