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Dordaviprone
go.drugbank.com/drugs/DB14844ApprovedInvestigationalFactor 4 (ATF4), and induction of endoplasmic reticulum (ER) stress response. … Dordaviprone is a first-in-class small molecule imipridone. On August 6, 2025, dordaviprone was granted accelerated approval by the FDA.
Synonyms: 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo(1,2-A)pyrido(3,4-E)pyrimidin-5(4H)-one, 2,4,6,7,8,9-Hexahydro-4-((2-methylphenyl)methyl)-7-phenylmethyl)imidazo)(1,2-a)pyrido(3,4-e)pyrimidin-5(1H)-oneCategories: MATE 1 Inhibitors, MATE 2 InhibitorsRilpivirine
go.drugbank.com/drugs/DB08864ApprovedInvestigationalRilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients.[A31328] It is a diarylpyrimidine derivative. … [A31329] The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potency and reduces the chance of resistance compared to other NNRTI's
Synonyms: 4-{[4-({4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrileMixtures: ODEFSEY® 200 MG - 25 MG - 25 MG TABLETAS RECUBIERTAS, Odefsey® (200mg Emtricitabine/25mg Rilpivirine/25mg Tenofovir alafenamide) film coated tabletsCapsaicin
go.drugbank.com/drugs/DB06774ApprovedInvestigationalCapsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. … Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements
Mixtures: Trubrexa Patch ER, NuDroxiPAK E-400Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Cytochrome P-450 Substrates(E)-2-Fluoro-P-Hydroxycinnamate
go.drugbank.com/drugs/DB02384ExperimentalSynonyms: (E)-2-Fluoro-P-HydroxycinnamateVaricella zoster virus envelope glycoprotein e
go.drugbank.com/drugs/DB33826InvestigationalSynonyms: Varicella zoster virus envelope glycoprotein eKOS-1584
go.drugbank.com/drugs/DB05903InvestigationalKOS-1584 is a second-generation epothilone. Epothilones are anticancer agents with a taxane-like mechanism of action that have demonstrated activity in taxane-resistant tumors. … KOS-1584 is a second-generation compound with increased potency, favorable tissue distribution, and ease of formulation.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsSynonyms: (E)-9,10-Dehydroepothilone D, (E)-9,10-Didehydroepothilone DAxitinib
go.drugbank.com/drugs/DB06626ApprovedInvestigationalAxitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). … [A179398] It is most commonly marketed under the name Inlyta® and is available in oral formulations.
Synonyms: N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamideCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexAB-207
go.drugbank.com/drugs/DB22801InvestigationalAB-207 is under investigation in clinical trial NCT06456073 (E-CEL UVEC Treatment for Anal Fissures).
Synonyms: E-CEL UVE, E-CEL UVEC cellsD-alpha-Tocopherol acetate
go.drugbank.com/drugs/DB14002ApprovedNutraceuticalVet approvedMoreover, RRR-alpha-tocopherol acetate is a relatively stabilized form of vitamin E that is most commonly used as a food additive when needed [A32451]. … Nevertheless, vitamin E is known to be a fat-soluble antioxidant that has the capability to neutralize endogenous free radicals.
Synonyms: Vitamin E acetate, D-, D-alpha tocoferil acetateMixtures: Vitamin A C E W.niacinam.beta Car.and Min., C.E.b12 Complex Pwr