KOS-1584 is a second-generation epothilone. Epothilones are anticancer agents with a taxane-like mechanism of action that have demonstrated activity in taxane-resistant tumors. KOS-1584 is a second-generation compound with increased potency,...
- Mechanism
- Curator reviewed
Epothilones are highly potent microtubulin stabilizing compounds with a similar mechanism of action to taxanes and broad applicability in a wide range of tumors. Epothilones are active in both taxane-sensitive and taxane-resistant cancers and have demonstrated low susceptibility to tumor resistance mechanisms.
- Primary indication
- Investigated for use/treatment in solid tumors.Curator reviewed
- Formula / weight
- C27H39NO5S · 489.67 g/mol (avg)
- Also known as
- (E)-9,10-Dehydroepothilone D · (E)-9,10-Didehydroepothilone D
- Code names
- KOS-1584 · R-1645
Resolves to
XAYAKDZVINDZGB-BMVMHAJPSA-NSMILESC[C@H]1\C=C\C\C(C)=C/C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\C1=CSC(C)=N1What you can answer from here — as of June 12, 2020
Which companies are running trials of KOS-1584, in which indications and phases, and which of those programs are still active?
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