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Fezolinetant
go.drugbank.com/drugs/DB15669ApprovedInvestigational[A259591,A259542] NK3, one of the receptors expressed in KNDy neurons, is activated by neurokinin B and can thus induce the release of GnRH. … [A259591,A259542] By antagonizing NK3 receptors, neuronal signalling can be dampened to reduce VMS.
Categories: Genito Urinary System and Sex HormonesRotavirus vaccine
go.drugbank.com/drugs/DB10276ApprovedInvestigationalRotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. … [L1117] Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains.
Givinostat
go.drugbank.com/drugs/DB12645ApprovedInvestigationalIn the context of muscular dystrophy, inhibitors of HDAC appear to exert their therapeutic effects by targeting pathogenic processes that cause inflammation and muscle loss. … It has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease and juvenile idiopathic arthritis, cancers like leukemia and lymphoma, as well as several muscular dystrophies
Davesomeran
go.drugbank.com/drugs/DB17091ApprovedInvestigationalSimilar to the previous Moderna COVID-19 vaccine, Moderna Bivalent vaccine encodes the full-length pre-fusion stabilized spike (S) protein to elicit an immune response. … [L43882] A phase 2 and 3 open-label study in participants 18 years or older who had previously received a two-dose primary series and one booster dose of Moderna COVID-19 Vaccine demonstrated that the
Pirfenidone
go.drugbank.com/drugs/DB04951ApprovedInvestigational[A251370] It is an antifibrotic agent with anti-inflammatory and antioxidant properties [A251370] that is used to treat idiopathic pulmonary fibrosis (IPF),[L26801] which is a chronic, progressive form … [A251370] While its mechanism of action is not yet fully understood, pirfenidone is proposed to primarily regulate tumor necrosis factor (TNF) pathways and modulate cellular oxidation.
Categories: Antineoplastic and Immunomodulating AgentsBlock, Heart
go.drugbank.com/conditions/DBCOND0164920Drugs: HyoscyamineSynonyms: Other and unspecified atrioventricular blockMedication Resistant Epilepsy
go.drugbank.com/conditions/DBCOND0117829Drugs: DiazepamSynonyms: Epilepsy and recurrent seizuresIndian frankincense
go.drugbank.com/drugs/DB14275ApprovedInvestigationalIndian frankincense is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Mixtures: ACTS38 BoswelliaGel (100ml)Iophendylate
go.drugbank.com/drugs/DB01187ApprovedIophendylate is a mixture of isomers used as contrast medium, mainly for brain and spinal cord visualization. Iophendylate is a myelographic oil-ester (U.S. Patent 2,348,231). … In 1942 Van Wagenen (a neurosurgical colleague of Warrens, at the University of Rochester) identified Iophendylate as causing chemical meningitis in 30 patients where "space-displacing masses within the
Categories: Compounds used in a research, industrial, or household settingCatridecacog
go.drugbank.com/drugs/DB09310ApprovedCoagulation Factor XIII A-Subunit (Recombinant) is available in the US as the commmercially available product Tretten, and in the EU as NovoThirteen. … It is subsequently isolated by homogenization of cells and purification by several chromatography steps, including hydrophobic interaction and ion exchange chromatography [FDA Label].
Categories: Blood and Blood Forming Organs