Rotavirus vaccine
Explore a selection of our essential drug information below, or:
Identification
- Brand Names
- Rotarix, Rotateq
- Generic Name
- Rotavirus vaccine
- DrugBank Accession Number
- DB10276
- Background
Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration.2 Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains.1 Rotarix is a live attenuated vaccine containing the 89-12 human strain.Label Rotavirus vaccines are 90% effective in protecting against severe rotavirus infection.2
- Type
- Biotech
- Groups
- Approved
- Biologic Classification
- Vaccines
Attenuated - Synonyms
- Rota virus, live attenuated
- Rotavirus vaccine, live, oral
Pharmacology
- Indication
Rotarix is indicated for prevention of rotavirus gastroenteritis caused by G1, G3, G4, and G9 types in infants aged 6-24 weeks Label.
Rotateq is indicated for the prevention of rotavirus gastroenteritis caused by G1, G2, G3, G4, and G9 types in infants aged 6-32 weeks 1.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Prevention of Rotavirus gastroenteritis caused by rotavirus g1 •••••••••••• Prevention of Rotavirus gastroenteritis caused by rotavirus g1 •••••••••••• Prevention of Rotavirus gastroenteritis caused by rotavirus g2 •••••••••••• Prevention of Rotavirus gastroenteritis caused by rotavirus g3 •••••••••••• Prevention of Rotavirus gastroenteritis caused by rotavirus g3 •••••••••••• - Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Rotarix and Rotateq contain live attenuated and live virus respectively. The virus replicates in the intesine and interacts with the patient's immune system to produce immunity Label,1. Seroconversion has been defined as the appearance of anti-rotavirus IgA antibodies at concentrations greater than 20 U/mL post-vaccination in the serum of infants previously negative for rotavirus Label.
- Mechanism of action
The exact mechanism specific to the rotavirus vaccines' interaction with the immune system is uncharacterized Label,1.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
The median duration of viral shedding was observed to be 10 days Label.
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Rotavirus vaccine may produce severe diarrhea and vomiting as a result of rotavirus infection Label. Post marketing reports suggest an increased risk of intussusception with rotavirus vaccine but this is unsupported by clinical data.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbatacept The therapeutic efficacy of Rotavirus vaccine can be decreased when used in combination with Abatacept. Adalimumab The therapeutic efficacy of Rotavirus vaccine can be decreased when used in combination with Adalimumab. Aldesleukin The therapeutic efficacy of Rotavirus vaccine can be decreased when used in combination with Aldesleukin. Alefacept The therapeutic efficacy of Rotavirus vaccine can be decreased when used in combination with Alefacept. Alemtuzumab The therapeutic efficacy of Rotavirus vaccine can be decreased when used in combination with Alemtuzumab. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Human Rotavirus A type G1P(8) strain RIX4414 live antigen KZ3L01D2PC Not Available Not applicable Human Rotavirus A type G1P7(5) strain WI79 live antigen 3L3RG28B7Q Not Available Not applicable Human Rotavirus A type G2P7(5) strain SC2 live antigen JU499IS53H Not Available Not applicable Human Rotavirus A type G3P7(5) strain WI78 live antigen Z65J02I7CW Not Available Not applicable Human Rotavirus A type G4P7(5) strain BRB live antigen 6334XMP4KC Not Available Not applicable Human Rotavirus A type G6P1A(8) strain WI79 live antigen L1977Q86S5 Not Available Not applicable - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Rotarix Suspension 1000000 CCID50/1.5mL Oral Glaxosmithkline Inc 2008-12-16 Not applicable Canada Rotarix Suspension 1000000 CCID50/ml Oral Glaxosmithkline Biologicals S.A. 2021-02-11 Not applicable EU Rotarix Suspension 1000000 CCID50/ml Oral Glaxosmithkline Biologicals S.A. 2021-02-11 Not applicable EU Rotarix Suspension 1000000 CCID50/ml Oral Glaxosmithkline Biologicals S.A. 2021-02-11 Not applicable EU Rotarix Suspension 1000000 CCID50/ml Oral Glaxosmithkline Biologicals S.A. 2021-02-11 Not applicable EU - Mixture Products
Categories
- ATC Codes
- J07BH01 — Rota virus, live attenuated
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- Not Available
References
- General References
- External Links
- PubChem Substance
- 347910468
- Wikipedia
- Rotavirus_vaccine
- FDA label
- Download (227 KB)
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Completed Not Available Gastroenteritis / Gastroenteritis Acute 1 somestatus stop reason just information to hide Not Available Completed Not Available Infections, Rotavirus 5 somestatus stop reason just information to hide Not Available Completed Not Available Infections, Rotavirus / Rotavirus Vaccines 1 somestatus stop reason just information to hide Not Available Completed Prevention Diarrhoeal Disease 1 somestatus stop reason just information to hide Not Available Completed Prevention Infections, Rotavirus / Intestinal Bacteria Flora Disturbance / Streptococcal Pneumonia / Tetanus / Vaccine Reaction 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Kit Oral 1000000 [CCID_50]/1mL Kit; powder, for solution Oral 1000000 [CCID_50]/1mL Powder, for suspension Oral 1000000 CCID50/ml Solution Oral 1000 [CCID_50]/1mL Suspension Oral 1000000 CCID50/1.5mL Suspension Oral 1000000 CCID50/ml Suspension Oral 1000000 [CCID_50]/1mL Suspension Oral 1 ml Suspension Oral 1000000 [CCID_50]/1.5mL Solution Oral Solution Oral 2210000 unit / dose Solution Oral 2 ml Suspension Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at November 30, 2015 21:23 / Updated at December 05, 2023 12:31