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Baclofen
go.drugbank.com/drugs/DB00181ApprovedInvestigationalAlthough originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. … [A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury.
Mixtures: Innoprax-5Products: LIORESAL 10 MG TABLET, 50 ADET, COLMIFEN 10 TABLET 10 mgIodine I-131 monoclonal antibody 81C6
go.drugbank.com/drugs/DB16197InvestigationalNeuradiab is under investigation in clinical trial NCT00615186 (Glioblastoma Multiforme (GBM) Locoregional Agent Survival Study - Anti-tenascin Radiolabeled Antibody Therapy).
Synonyms: Moab, 81c6, murine, iodine-I-131 radiolabeled, to human gliomaFlucloxacillin
go.drugbank.com/drugs/DB00301ApprovedInvestigationalWithdrawnAntibiotic analog of cloxacillin.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: (2S,5R,6R)-6-({[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolylpenicillinPinaverium
go.drugbank.com/drugs/DB09090ApprovedInvestigationalAlthough it is not a currently approved drug by the FDA, pinaverium is available in over 60 countries including Canada. … It is shown to relieve GI spasm and pain, transit disturbances and other symptoms related to motility disorders [A19697] and may be considered as effective first-lline therapy for patients with irritable
Mixtures: BROMUX D® 100/300 MG CÁPSULA.Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSirolimus
go.drugbank.com/drugs/DB00877ApprovedInvestigational[A242372] In November 2000, the drug was recognized by the European Agency as an alternative to calcineurin antagonists for maintenance therapy with corticosteroids. … rapamycin (mTOR), which is a serine/threonine-specific protein kinase that regulates cell growth, proliferation, and survival. mTOR is an important therapeutic target for various diseases, as it was shown to
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: RAPAMUNE 1 MG 100 FILM DRAJE, RAPAMUNE 0.5 MG TABLET ,100 ADETMethylene blue
go.drugbank.com/drugs/DB09241ApprovedInvestigationalHistorically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs entered the market. … clinical trials to be an inhibitor of Tau protein aggregation.
Mixtures: Urimar-T, Urimar-TCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 CYP1A2 InducersZelpultide alfa
go.drugbank.com/drugs/DB18587InvestigationalZelpultide alfa is a recombinant human surfactant protein D.
Synonyms: PULMONARY SURFACTANT-ASSOCIATED PROTEIN D (HUMAN RECOMBINANT GLYCOEXPRESS MYELOMA CELL HOMOTRIMERIC QUADRAPLEX AT-100)Estramustine
go.drugbank.com/drugs/DB01196ApprovedWithdrawnA nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: ESTRACYT 300 MG ENJEKTABL FLAKON, 10 ADET, ESTRACYT 140 MG KAPSUL, 100 ADETAvena sativa pollen
go.drugbank.com/drugs/DB10377ApprovedAvena sativa pollen is the pollen of the Avena sativa plant. Avena sativa pollen is mainly used in allergenic testing.
Synonyms: Avena sativa pollenProducts: Center-AL - Avena Sativa Pollen, Pollens - Grasses, Oats, Common, Cultivated Avena sativaAmisulpride
go.drugbank.com/drugs/DB06288ApprovedInvestigational[A6755] Amisulpride predominantly works in the limbic system, which explains its relatively lower risk of extrapyramidal adverse effects compared to other atypical antipsychotic agents. … In the US, the intravenous formulation of amisulpride is used to treat and prevent postoperative nausea and vomiting in adults, either as monotherapy or in combination with another antiemetic agent of
Synonyms: 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-O-anisamide, 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamideCategories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2A Receptor Antagonists