Flucloxacillin is a narrow spectrum penicillin antibiotic that exerts specific activity against Gram positive organisms in skin and soft tissue infections, except those caused by methicillin resistant staphylococcus aureus (MRSA). Antibiotic analog of cloxacillin.
- Mechanism
- Curator reviewed
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, flucloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that flucloxacillin interferes with an autolysin inhibitor.
- Primary indication
- Used to treat bacterial infection by susceptible microorganisms.Curator reviewed · 1 structured indication
- Formula / weight
- C19H17ClFN3O5S · 453.872 g/mol (avg)
- First approval
- Canada, 1981
- Also known as
- Floxacillin
- Code names
- BRL-2039
Resolves to
UIOFUWFRIANQPC-JKIFEVAISA-NSMILES[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)C1=C(C)ON=C1C1=C(Cl)C=CC=C1F)C(O)=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Flucloxacillin, and which of those have an active Phase 3 trial?
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