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Gag-Pol polyprotein
go.drugbank.com/bio_entities/BE0001781TargetSIV-macGag-Pol polyprotein and Gag polyprotein may regulate their own translation, by the binding genomic RNA in the 5'-UTR. … At low concentration, Gag-Pol and Gag would promote translation, whereas at high concentration, the polyproteins encapsidate genomic RNA and then shut off translation (By similarity).
Polypeptides: Gag-Pol polyproteinSynonyms: Pr160Gag-PolGag-Pol polyprotein
go.drugbank.com/bio_entities/BE0001907TargetRSV-SRACapsid protein p27: Self-associates to form the irregular polyhedron core composed of hexamers and pentamers, that encapsulates the genomic RNA-nucleocapsid complex. Assembles as a tube in vitro. Binds to inositol hexakisphosphate (IP6),...
Polypeptides: Gag-Pol polyproteinSynonyms: Gag-Pro-Pol polyproteinGag-Pol polyprotein
go.drugbank.com/bio_entities/BE0004120TargetGag-Pol polyprotein may regulate its own translation, by the binding genomic RNA in the 5'-UTR. … Gag-Pol polyprotein Mediates, with Gag polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical
Polypeptides: Gag-Pol polyproteinSynonyms: Pr160Gag-PolAtorvastatin
go.drugbank.com/drugs/DB01076ApprovedInvestigationalor angioplasty following a heart attack. … the number of major cardiovascular events (heart attack, stroke, coronary revascularization, and coronary death) for every 1 mmol/L reduction in LDL without any significant side effects or risks.
Mixtures: TIAZOMET ® A 40/10 TABLETASCategories: Hypolipidemic Agents Indicated for HyperlipidemiaTadalafil
go.drugbank.com/drugs/DB00820ApprovedInvestigationalIn contrast to other PDE5 inhibitors like [sildenafil], tadalafil has greater selectivity for PDE5 and a longer half-life which has made it a more suitable option for chronic once-daily dosing in the treatment … [L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH.
Categories: Antihypertensives for Pulmonary Arterial HypertensionProducts: LUDIKA TABLETAS RECUBIERTAS POR 20 MG, N/aPoor blood circulation
go.drugbank.com/conditions/DBCOND0108559Drugs: NonivamideSynonyms: Poor blood circulationSertraline
go.drugbank.com/drugs/DB01104ApprovedInvestigationalSertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. … Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.
Categories: Monoamine Oxidase A Substrates, Antidepressive Agents Indicated for DepressionProducts: Pro-sertraline, SERTRALIN 1A PHARMA 50MGLevodopa
go.drugbank.com/drugs/DB01235ApprovedInvestigationalLevodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. … The first developed drug product that was approved by the FDA was a levodopa and carbidopa combined product called Sinemet that was approved on May 2, 1975[A177781,L6133].
Synonyms: L-DOPA, 3-Hydroxy-L-tyrosineMixtures: MADOPAR ROCHE 125 CAPSULE, MADOPAR ROCHE TABLET 250MGMetoclopramide
go.drugbank.com/drugs/DB01233ApprovedInvestigationalIt can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures. … Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system.
Categories: Drugs for Functional Gastrointestinal DisordersProducts: CARNOTPRIM LP, Metoperan Solution for Injection 5mg/mL