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Displaying results 4091 - 4100 of 10000 in total
  1. Drug

    Indium In-111 pentetate

    go.drugbank.com/drugs/DB09425
    ApprovedInvestigational

    Indium In-111 pentetate disodium is a radioactive diagnostic indicated for use in radionuclide cisternography. … Decay of In-111 by electron capture allows for detection with a gamma camera for visualization of the brain and spinal column.

    Synonyms: Indium In 111 pentetate, Indium In-111 pentetateSalts: Indium In-111 pentetate disodium
  2. Drug

    Sibutramine

    go.drugbank.com/drugs/DB01105
    ApprovedIllicitWithdrawn

    Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. … In October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.

  3. Drug

    Insulin beef

    go.drugbank.com/drugs/DB09456
    Approved

    Insulin beef has been discontinued in the US and Canada since 2017.[L10827]

    Categories: Drugs Used in Diabetes
  4. Drug

    XMT-1001

    go.drugbank.com/drugs/DB06069
    Investigational

    XMT-1001 has demonstrated an improved therapeutic window as compared with CPT and irinotecan in human tumor xenografts models … In this novel CPT pro-drug, CPT is conjugated with a 70 kDa biodegradable hydrophilic polyacetal, poly (1-hydroxymethylene hydroxylmethylformal).

    Categories: Compounds used in a research, industrial, or household setting
  5. Drug

    Canis lupus familiaris dander

    go.drugbank.com/drugs/DB11018
    Approved

    Canis lupus familiaris dander is used in allergenic testing.

    Categories: Non-Standardized Animal Dander Allergenic Extract
  6. Drug

    Nalbuphine

    go.drugbank.com/drugs/DB00844
    ApprovedInvestigational

    It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. … Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States.

    Synonyms: N-cyclobutylmethyl-4,5α-epoxy-3,6α,14-morphinantriol
  7. Drug

    Bioymifi

    go.drugbank.com/drugs/DB17493
    Experimental

    Upon binding to the death receptor 5 (DR5) on cancer cells, bioymifi triggers apoptosis, possibly through a caspase-dependent pathway. Bioymifi is currently being investigated as an anti-tumor agent.

  8. Drug

    House dust

    go.drugbank.com/drugs/DB10345
    Approved

    House dust allergenic extract is used in allergenic testing.

    Categories: Non-Standardized House Dust Allergenic Extract
  9. Target

    Botulinum neurotoxin type B

    go.drugbank.com/bio_entities/BE0001263
    TargetEnzymeClostridium botulinum

    BoNT/B is a 'coincidence detector'; it requires simultaneous binding to coreceptor GT1b and low pH to transform into a membrane-bound, oligomeric channel (PubMed:21925111, PubMed:22720883). … Once in the cytosol the disulfide bond linking the 2 subunits is reduced and LC cleaves its target protein on synaptic vesicles, preventing their fusion with the cytoplasmic membrane and thus neurotransmitter

    Synonyms: BoNT/B
  10. Target

    Botulinum neurotoxin type D

    go.drugbank.com/bio_entities/BE0009354
    TargetClostridium botulinum

    Thus a protein receptor for this BoNT serotype has yet to be definitively proven. Recognizes at least 1 complex polysialylated ganglioside found on neural tissue. … Once in the cytosol the disulfide bond linking the 2 subunits is reduced and LC cleaves its target protein on synaptic vesicles, preventing their fusion with the cytoplasmic membrane and thus neurotransmitter

    Synonyms: BoNT/D