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Nafamostat
go.drugbank.com/drugs/DB12598InvestigationalNafamostat is a synthetic serine protease inhibitor that is commonly formulated with hydrochloric acid due to its basic properties. … The use of nafamostat in Asian countries is approved as an anticoagulant therapy for patients undergoing continuous renal replacement therapy due to acute kidney injury.
Synonyms: p-Guanidinobenzoic acid ester with 6-hydroxy-2-naphthamidineLX1031
go.drugbank.com/drugs/DB05199InvestigationalLX1031 was generated by Lexicon medicinal chemists, and its target was internally identified as a key control point for the regulation of peripheral serotonin levels. … LX1031 is an orally-dosed drug candidate for irritable bowel syndrome and other gastrointestinal disorders.
Naratriptan
go.drugbank.com/drugs/DB00952ApprovedNaratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. It is typically used for the treatment of migraine headaches.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: N-methyl-2-(3-(1-methylpiperiden-4-yl)indole-5-yl)ethanesulfonamide, N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamideNitrazepam
go.drugbank.com/drugs/DB01595ApprovedA benzodiazepine derivative used as an anticonvulsant and hypnotic.
Synonyms: 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one, 2,3-dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-oneCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingOPC-14523
go.drugbank.com/drugs/DB05422ExperimentalOPC-14523 is an antidepressant drug developed by Otsuka America Pharmaceutical.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingDutogliptin
go.drugbank.com/drugs/DB11723InvestigationalDutogliptin has been investigated for the treatment of Diabetes Mellitus, Type II.
Lintitript
go.drugbank.com/drugs/DB04867ExperimentalLintitript is a new, highly specific and potent CCK-A receptor antagonist.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingDiacerein
go.drugbank.com/drugs/DB11994ApprovedInvestigationalWithdrawnDiacerein is a prodrug which is metabolized to rhein. … Diacerein is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C9 InhibitorsProducts: FLAMTOR®, ARTOSAN® CAPSULAUC-781
go.drugbank.com/drugs/DB05871InvestigationalUC-781 is a thiocarboxanilide non-nucleoside reverse transcriptase inhibitor (NNRTI). It is a topical microbicide targeted against the AIDS virus.
Categories: Heterocyclic Compounds, 1-RingKIN-3248
go.drugbank.com/drugs/DB17587Investigational[A257714] While effective, disease progression may occur 6 to 8 months after treatment with currently approved FGFR inhibitors is started, and this effect is usually associated with on-target resistance … KIN-3248 is a small molecule that targets and inhibits oncogenic fibroblast growth factor receptors (FGFRs).