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Nuclear factor NF-kappa-B p100 subunit
go.drugbank.com/bio_entities/BE0002387TargetHumansNF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as in...
Synonyms: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2Hepatic sodium/bile acid cotransporter
go.drugbank.com/bio_entities/BE0003644TransporterTargetHumansAs a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (...
Synonyms: Cell growth-inhibiting gene 29 proteinCloxazolam
go.drugbank.com/drugs/DB01553ExperimentalThe usual dose of cloxazolam in adults is 3-12mg/day for anti-anxiety. … Cloxazolam is a benzodiazepine with anxiolytic, sedative/hypnotic, muscle relaxant, and antiepileptic effects.
Categories: Heterocyclic Compounds, 2-RingProducts: OLCADIL ® 2 MG COMPRIMIDOS, OLCADIL ® 1 MG COMPRIMIDOSSR-9009
go.drugbank.com/drugs/DB14013ExperimentalSR-9009 is a REV-ERB agonist. … SR-9011 has been demonstrated that it is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues
Synonyms: 1-Pyrrolidinecarboxylic acid, 3-((((4-chlorophenyl)methyl)((5-nitro-2-thienyl)methyl)amino)methyl)-, ethyl esterCategories: Heterocyclic Compounds, 1-RingAutologous Non-Hematopoietic Peripheral Blood Stem Cells
go.drugbank.com/drugs/DB15867InvestigationalAutologous non-hematopoietic peripheral blood stem cells have been created into a formulation for use in a clinical trial (NCT04473170) by the Abu Dhabi Stem Cells Center. … The cells have the characterizations of CD90+, CD133+, Oct-4+, CD45-, and CD71-.[L16363]
Sizofiran
go.drugbank.com/drugs/DB13128InvestigationalSizofiran has been used in trials studying the treatment of Cervical Cancer. … A beta-D-glucan obtained from the Aphyllophoral fungus Schizophyllum commune. It is used as an immunoadjuvant in the treatment of neoplasms, especially tumors found in the stomach.
Categories: Compounds used in a research, industrial, or household settingLortalamine
go.drugbank.com/drugs/DB09187ExperimentalLortalamine (LM-1404) is a selective norepinephrine reuptake inhibitor developed in the 1980s. … This drug never made it past clinical trials, likely due to ocular toxicity in animals, but has been used in positron emission tomography studies to label norepinephrine transporters.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingCyanamide
go.drugbank.com/drugs/DB02679ExperimentalA cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide.
Placental Mesenchymal Stem Cells
go.drugbank.com/drugs/DB15730InvestigationalThe placenta serves many purposes, with one of the many being a bank of mesenchymal stem cells (MSCs).
Venetoclax
go.drugbank.com/drugs/DB11581ApprovedInvestigationalPreviously, this drug was indicated only for patients with 17p gene deletion [F2130]. … Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process [A18565], [A18566].
Synonyms: 4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(1H-pyrrolo(2,3-b)pyridin-5-yloxy)benzamide, 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamideCategories: BCL-2 Inhibitor, P-glycoprotein substrates with a Narrow Therapeutic Index