Hepatic sodium/bile acid cotransporter

BE0003644ProteinHumansSLC10A1

As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and... It is acted on by 37 drugs in DrugBank.

Gene name
SLC10A1
UniProtKB entry
Q14973Swiss-Prot
Cellular location
Cell membrane
Residues / weight
349 residues · 38,119 Da
Also known as
Cell growth-inhibiting gene 29 protein · Na(+)/bile acid cotransporter · Na(+)/taurocholate transport protein · NTCP · SLC10A1

Resolves to

Protein
UniProtQ14973UniProt nameNTCP_HUMAN
Gene
HGNCHGNC:10905NCBI Gene6554GenBank410214GeneCardsSLC10A1
Pharmacology
IUPHAR/GtoPdb959KEGGhsa:6554
Structure
PDB7FCIPDB7PQGPDB7PQQ
Drugs

What you can answer from here — as of September 03, 2024

37DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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71+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hepatic sodium/bile acid cotransporter, how selective are they, and which programs against it are still in active trials?

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