Nuclear factor NF-kappa-B p100 subunit

BE0002387ProteinHumansNFKB2

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many... It is acted on by 20 drugs in DrugBank.

Gene name
NFKB2
UniProtKB entry
Q00653Swiss-Prot
Cellular location
Nucleus
Residues / weight
900 residues · 96,748 Da
Also known as
DNA-binding factor KBF2 · H2TF1 · Lymphocyte translocation chromosome 10 protein · LYT10 · Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2

Resolves to

Protein
UniProtQ00653UniProt nameNFKB2_HUMAN
Gene
HGNCHGNC:7795NCBI Gene4791GeneCardsNFKB2
Pharmacology
KEGGhsa:4791
Structure
PDB1A3QPDB2D96PDB3DO7
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nuclear factor NF-kappa-B p100 subunit, how selective are they, and which programs against it are still in active trials?

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