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Displaying results 4141 - 4150 of 10000 in total
  1. Target

    Caspase-4

    go.drugbank.com/bio_entities/BE0009964
    TargetHumans

    Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS, GSDMD and IL18 (PubMed:15326478, PubMed:23516580, PubMed:26375003, PubMed:28314590, … Plays a crucial role in the restriction of S.typhimurium replication in colonic epithelial cells during infection (PubMed:25121752, PubMed:25964352).

    Polypeptides: Caspase-4Synonyms: CASP-4
  2. Target

    Myosin-4

    go.drugbank.com/bio_entities/BE0021470
    TargetHumans

    Muscle contraction

    Polypeptides: Myosin-4Synonyms: Myosin heavy chain 4
  3. Drug

    Dextrose, unspecified form

    go.drugbank.com/drugs/DB09341
    ApprovedInvestigationalVet approved

    L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. … Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants.

    Mixtures: Delflex A Perit.dial.soln W.4.25%dext.low mg, Delflex A Perit.dial.solN.W.1.5%dext.low mgCategories: Compounds used in a research, industrial, or household setting
  4. Drug

    Fish liver oil

    go.drugbank.com/drugs/DB15481
    ApprovedWithdrawn

    Mixtures: A+ Zinc Tab, Formula F L WProducts: Vitamine A 10000 U.I., Vitamine A 10000ui Capsule
  5. Drug

    Thiocolchicoside

    go.drugbank.com/drugs/DB11582
    Investigational

    Thiocolchicoside is a semi-synthetic derivative of the colchicine, a natural anti-inflammatory glycoside which originates from the flower seeds of _Superba gloriosa_. … It is a muscle relaxant with anti-inflammatory and analgesic effects. It has potent convulsant activity and should not be administered to individuals prone to seizures.[L1663]

    Synonyms: Thiocolchicine 2-glucoside analogMixtures: DEKSİT 25 MG/4 MG TABLET, NAPROXENO 250 MG+TIOCOLCHICOSIDO 4 MG
  6. Drug

    Gadoversetamide

    go.drugbank.com/drugs/DB00538
    Approved

    Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver.

    Categories: Compounds used in a research, industrial, or household settingProducts: CIPROFLOXACINA 100 MG / 10 ML, OPTIMARK 500 MIKROMOL/ML IV. ENJ. ICIN COZ. ICEREN FLAKON, 10 ML
  7. Drug

    Nimesulide

    go.drugbank.com/drugs/DB04743
    ApprovedWithdrawn

    Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. … Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.

    Mixtures: ETNA COMBO 100 MG/8 MG TABLET, 14 ADET, NİMES COMBO 100 MG / 8 MG TABLET , 14 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  8. Drug

    Cocaine

    go.drugbank.com/drugs/DB00907
    ApprovedIllicitInvestigational

    It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. … It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester, methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
  9. Drug

    Melatonin

    go.drugbank.com/drugs/DB01065
    ApprovedInvestigationalNutraceuticalVet approved

    Reduced melatonin production has also been proposed as a likely factor in the significantly higher cancer rates in night workers. … Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958.

    Synonyms: 5-methoxy-N-acetyl tryptamine, N-[2-(5-methoxyindol-3-yl)ethyl]acetamideInternational brands: Mela-T
  10. Drug

    Brinzolamide

    go.drugbank.com/drugs/DB01194
    Approved

    [A2051] Brinzolamide was approved by the FDA in 1998 as a standalone product and in 2013 as a combination product with brimonidine tartrate. … [L35310,L35315] In Europe, it was also approved as a combination product with timolol in 2008.[L35320]

    Mixtures: BRINZOLAMIDE E TIMOLOLO EG, BRINZOLAMIDE E TIMOLOLO EGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates