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Docetaxel
go.drugbank.com/drugs/DB01248ApprovedInvestigational[A259671] The use of docetaxel may lead to udesired outcomes such as hepatic impairment, hematologic effects, enterocolitis and neutropenic colitis, hypersensitivity reactions, fluid retention, second … [L46466] Docetaxel was approved by the FDA in 1996 and is available in solution for injection for intravenous or parenteral administration.[A259676]
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: Docetaxel Amring 20 mg/ml Konzentrat zur Herstellung einer Infusionslösung, Docetaxel Ebewe 10 mg/ml Konzentrat zur Herstellung einer InfusionslösungUrofollitropin
go.drugbank.com/drugs/DB00094ApprovedVet approvedWithdrawnUrofollitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF).
Products: BRAVELLE POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 75 IU, Fostimon 75 IU powder and solvent for solution for injectionAmivantamab
go.drugbank.com/drugs/DB16695ApprovedInvestigationalAmivantamab, also known as JNJ-61186372, is an anti-EGFR-MET bispecific antibody, derived from Chinese hamster ovary cells, approved for the treatment of adult patients with locally advanced or metastatic … [A235133] Amivantamab was granted FDA approval on 21 May 2021,[L34193] followed by the approval by the EMA on 9 December 2021 [L41474] and Health Canada on 30 March 2022.
Products: RYBREVANT 350mg/7mL Concentrate for Solution for InfusionTrastuzumab deruxtecan
go.drugbank.com/drugs/DB14962ApprovedInvestigationalTrastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. … [L10842] It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from other members of its class.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: ENHERTU POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/VIALTozinameran
go.drugbank.com/drugs/DB15696ApprovedInvestigationalIt is designed to induce immunity against SARS-CoV-2, the virus responsible for causing COVID-19. … [L26956] Fact sheets for caregivers, recipients, and healthcare providers are now available.
Products: Comirnaty 3mcg Concentrate for Dispersion for Injection, Comirnaty Omicron XBB.1.5 10 micrograms/dose Dispersion for InjectionElosulfase alfa
go.drugbank.com/drugs/DB09051ApprovedInvestigationalIt was approved by the FDA in 2014 for the treatment of Morquio syndrome. Elosulfase alfa was developed by BioMarin Pharmaceutical Inc. and is marketed under the brand Vimizim™.
Products: Vimizim 1mg/ml Concentrate for Solution for InfusionDoxorubicin
go.drugbank.com/drugs/DB00997ApprovedInvestigationalDoxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970. Although they both have aglyconic and sugar moieties, doxor...
Synonyms: MTC-DOX for InjectionCategories: P-glycoprotein inducers, P-glycoprotein inhibitorsFludarabine
go.drugbank.com/drugs/DB01073ApprovedInvestigationalFludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Products: Neoflubin 25 mg/ml Konzentrat zur Herstellung einer Injektions- oder Infusionslösung, Fludarabin Accord 25 mg/ml Konzentrat zur Herstellung einer Injektions- oder InfusionslösungZanidatamab
go.drugbank.com/drugs/DB15471ApprovedInvestigational[A264718] In November 2024, the FDA granted an accelerated approval for zanidatamab for use in previously treated unresectable or metastatic HER2-positive biliary tract cancers.[L51908,L51903] … [A264718] It has been investigated for the treatment of HER2-positive solid tumors, including gastroesophageal, colorectal, and biliary tract cancers.
Categories: HER2 (Human Epidermal Growth Factor Receptor 2) inhibitorsSynonyms: IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS ERBB2 (EPIDERMAL GROWTH FACTOR RECEPTOR 2, RECEPTOR TYROSINEPROTEIN KINASE ERBB-2, EGFR2, HER2, HER-2, P185C-ERBB2, NEU, CD340)), HUMANIZED MONOCLONAL ANTIBODYEthyl biscoumacetate
go.drugbank.com/drugs/DB08794ApprovedWithdrawnEthyl biscoumacetate is a courmarin that is used as an anticoagulant. It has actions similar to those of Warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226)
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates