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Displaying results 421 - 430 of 10000 in total
  1. Drug

    Triclosan

    go.drugbank.com/drugs/DB08604
    Approved

    An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. … It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards

    Mixtures: KURSEPT %19 + %1 KREM (30 G), Nail MDSynonyms: 5-Chloro-2-(2,4-dichloro-phenoxy)-phenol, 2,4,4'-Trichloro-2'-hydroxydiphenyl ether
  2. Drug

    Ioxilan

    go.drugbank.com/drugs/DB09135
    ApprovedWithdrawn

    Ioxilan is a tri-iodinated diagnostic contrast agent.

    Categories: X-Ray Contrast Activity, X-Ray Contrast Media, IodinatedSynonyms: N-(2,3-dihydroxypropyl)-N’-(2- hydroxyethyl)-5-[N-(2,3-dihydroxypropyl) acetamido]-2,4,6-triiodoisophthal-amide
  3. Drug

    Cefradine

    go.drugbank.com/drugs/DB01333
    ApprovedWithdrawn

    A semi-synthetic cephalosporin antibiotic.

    Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersSynonyms: (6R,7R)-7-((R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, (6R,7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  4. Drug

    Amiodarone

    go.drugbank.com/drugs/DB01118
    ApprovedInvestigational

    Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings.

    Synonyms: 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran, 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuranCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 Substrates
  5. Drug

    Levoleucovorin

    go.drugbank.com/drugs/DB11596
    ApprovedInvestigational

    Levoleucovorin is the enantiomerically active form of Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin). … Levoleucovorin, as the product Fusilev (FDA), has an additional indication for use in combination chemotherapy with 5-fluorouracil in the palliative treatment of patients with advanced metastatic colorectal

    Categories: Vitamin B Complex, Heterocyclic Compounds, 2-RingSynonyms: (6S)-5-formyltetrahydrofolic acid, (6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid
  6. Drug

    Vinflunine

    go.drugbank.com/drugs/DB11641
    ApprovedInvestigational

    Like other vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and promotes cell death via apoptosis [L1396]. … Having an incidence of 429,700 new cases per year worldwide, urothelial carcinoma of the bladder is one of the most common malignancies that mostly affects individuals aged 50–79 years [A32626].

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 4'-deoxy-20',20'-difluoro-5'-norvincaleukoblastine, 20',20'-difluoro-3',4'-dihydrovinorelbine
  7. Drug

    Ivacaftor

    go.drugbank.com/drugs/DB08820
    ApprovedInvestigational

    It was approved by the Food and Drug Administration on January 31, 2012[L768], and by Health Canada in late 2012. … [L6841] Ivacaftor is administered as a monotherapy and also administered in combination with other drugs for the management of CF.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 InhibitorsSynonyms: N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
  8. Drug

    Ceforanide

    go.drugbank.com/drugs/DB00923
    Approved

    It has a longer elimination half-life than any currently available cephalosporin.

    Synonyms: (6R,7R)-7-[[2-[2-(aminomethyl)phenyl]acetyl]amino]-3-[[1-(carboxymethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[O-(aminomethyl)phenylacetamido]-3-[[[1-(carboxymethyl)-1H-tetrazol-5-yl]thio]methyl]-3-cephem-4-carboxylic acidCategories: Heterocyclic Compounds, 2-Ring
  9. Drug

    Gemcitabine

    go.drugbank.com/drugs/DB00441
    ApprovedInvestigational

    Gemcitabine is a nucleoside analog and a chemotherapeutic agent. It was originally investigated for its antiviral effects, but it is now used as an anticancer therapy for various cancers. … [A233135] Gemcitabine is a cytidine analog with two fluorine atoms replacing the hydroxyl on the ribose.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein substratesSynonyms: 4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one, 2'-Deoxy-2',2'-difluorocytidine
  10. Drug

    2-[(2,4-DICHLORO-5-METHYLPHENYL)SULFONYL]-1,3-DINITRO-5-(TRIFLUOROMETHYL)BENZENE

    go.drugbank.com/drugs/DB07620
    Experimental

    Synonyms: 2-[(2,4-DICHLORO-5-METHYLPHENYL)SULFONYL]-1,3-DINITRO-5-(TRIFLUOROMETHYL)BENZENE