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MYR-101
go.drugbank.com/drugs/DB17075InvestigationalIt is caused by a mutation in the aspartoacylase gene (_ASPA_), which leads to a deficiency of the aspartoacylase enzyme (ASPA). … MYR-101 (rAAV-Olig001-ASPA) is a recombinant adeno-associated virus (rAAV) vector-based gene therapy intended to treat Canavan disease.
IDM-4
go.drugbank.com/drugs/DB05438ExperimentalTrials of this drug have most likely been discontinued by the manufacturer. … IDM-4 is an immuno-designed molecule that completed phase I/II of investigation for the treatment of Leukemia.
Synonyms: IDM-4Erythroxylum catuaba bark
go.drugbank.com/drugs/DB14300Investigational"Catuaba" is a general term for a medicinal infusion created by the bark of plants belonging to the _Erythroxylum_ genus, though this name is also applied to infusions of plants belonging to other genera … [A215262] The infusion is thought to carry stimulant and aphrodisiac effects,[A215262] and catuaba made specifically with _Trichilia catigua_ has been investigated for use in depression.[A215267]
Mericitabine
go.drugbank.com/drugs/DB12045InvestigationalMericitabine has been investigated for the treatment of Hepatitis C, Chronic. Mericitabine is a polymerase inhibitor being developed for the treatment of chronic hepatitis C. … PSI-6130 is a pyrimidine nucleoside analog inhibitor of HCV RNA polymerase, an enzyme that is necessary for hepatitis C viral replication.
Categories: Heterocyclic Compounds, 1-RingACR-16
go.drugbank.com/drugs/DB05371InvestigationalACR16 has been successfully investigated in a Phase II multi-centre, randomised and placebo-controlled trial in patients with Huntington’s disease as well as in three Phase Ib studies within Huntington … ACR-16 is a dopamine stabilizer. ACR-16 is also being studied in other psychiatric and neurologic diseases.
AG-858
go.drugbank.com/drugs/DB05502InvestigationalTumor-derived HSP70-peptide complexes used in vaccine preparations have been shown to prime tumor immunity and tumor-specific T cells in animal models. … AG-858 (autologous heat-shock protein 70 peptide vaccine) is a recombinant cancer vaccine made with tumor-derived heat shock protein 70 (HSP70) peptide complexes.
Protein arginine N-methyltransferase 1
go.drugbank.com/bio_entities/BE0004597TargetHumansMay be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator
Synonyms: Interferon receptor 1-bound protein 4Fenoxaprop-ethyl
go.drugbank.com/drugs/DB05252ExperimentalFenoxaprop-ethyl has been investigated to treat chronic angina, the chest pain that occurs from inadequate blood flow to the coronary arteries around the heart. … Fenoxaprop-ethyl (organic nitrate combined with L-arginine), is an oral proprietary nitrate therapeutic shown to induce coronary vasodilation while overcoming the significant problem of drug tolerance.
Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingElacridar
go.drugbank.com/drugs/DB04881InvestigationalDevelopment is assumed to have been discontinued. … In many cases, the appearance of multidrug resistance in cancer is due to a change in expression of protein inhibitors. As of August 2007 elacridar was not listed on GSK's product pipeline.
Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 2-RingStabilin-2
go.drugbank.com/bio_entities/BE0004948TargetHumansPhosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). … Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature.
Synonyms: Hyaluronan receptor for endocytosis, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2