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Brinzolamide
go.drugbank.com/drugs/DB01194Approved[A2049,A2051] Although systemic anti-carbonic anhydrase (CA) therapy has been used for almost 50 years with varying degrees of success, systemic administration results in an increase in incidences of adverse … [A2051] Brinzolamide was approved by the FDA in 1998 as a standalone product and in 2013 as a combination product with brimonidine tartrate.
Mixtures: BRINZOLAMIDE E TIMOLOLO EG, BRINZOLAMIDE E TIMOLOLO EGCategories: Genito Urinary System and Sex Hormones, Cytochrome P-450 SubstratesCaffeine
go.drugbank.com/drugs/DB00201ApprovedInvestigational[T716] Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection. … This correlates to about 1 in 10 births.
Mixtures: THOMAPVRIN 250 mg/200 mg/50 mg TABLET, 20 ADET, COLDSAL 200 MG / 250 MG / 50 MG TABLET, 20 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsCisapride
go.drugbank.com/drugs/DB00604ApprovedWithdrawnThe FDA issued a warning letter regarding this risk to health care professionals and patients.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 SubstratesProducts: DISPEPRID 10 MG TABLET, 50 ADET, GASTRON 1 MG/1 ML SÜSPANSİYON, 200 MLYeast
go.drugbank.com/drugs/DB11017ApprovedYeast allergenic extract is used in allergenic testing.
Mixtures: Sperti Preparation H Hämorrhoidalsalbe, Sperti Preparation H HämorrhoidalzäpfchenProducts: FLORATIL® 250 MG CAPSULAS, FLORATIL® 250 MG MINI SACHETSPromethazine
go.drugbank.com/drugs/DB01069ApprovedInvestigational[A189901] Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting. … Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946.
Synonyms: (2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine, N-(2'-dimethylamino-2'-methyl)ethylphenothiazineMixtures: ARTU 100 ML SURUP, COPHADYL-E COUGH LINCTUSOfloxacin
go.drugbank.com/drugs/DB01165ApprovedInvestigationalA synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsSynonyms: 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acidAtazanavir
go.drugbank.com/drugs/DB01072ApprovedInvestigationalFood and Drug Administration (FDA) approved atazanavir on June 20, 2003.
Mixtures: ANCEF ® R, ANCEF ® RCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsDasatinib
go.drugbank.com/drugs/DB01254ApprovedInvestigational[A2226] The use of dasatinib was first approved by the FDA in 2006.[L45171,L45186] … [A11377,A33432] Dasatinib also inhibits a spectrum of kinases involved in cancer, including several SRC-family kinases.
Synonyms: N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesBendamustine
go.drugbank.com/drugs/DB06769ApprovedInvestigationalBendamustine is a nitrogen mustard drug which has been used in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL). … Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: XEBINA® 25 MG, BENDAMUSTINA EGCanrenoic acid
go.drugbank.com/drugs/DB09015ApprovedInvestigationalWithdrawnLike spironolactone, it is a prodrug, which is metabolized to canrenone in the body.
Products: Aldactone 200 mg/ 10 ml Injektionslösung, POTASSIO CANRENOATO EG