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Human interferon omega-1
go.drugbank.com/drugs/DB05472InvestigationalIt has been investigated both in single and combination treatment. The biological activities of IFN-omega 1 and its physiological role are not known to date. … Human interferon omega 1 (IFN-omega 1 = IFN-alpha II1) is a recently discovered protein structurally related to IFN-alpha and -beta.
Synonyms: IFN-ω, Interferon omega-1Sagopilone
go.drugbank.com/drugs/DB12391InvestigationalSagopilone has been used in trials studying the treatment of Melanoma, Neoplasms, CNS Disease, Breast Cancer, and Breast Neoplasms, among others. … It is a so-called fully synthetic epothilone and is the first such compound to be in clinical development to combat several forms of cancer.
Categories: Cytochrome P-450 CYP3A Inhibitors, Heterocyclic Compounds, 1-RingAT2220
go.drugbank.com/drugs/DB05200InvestigationalAT2220 has been shown to increase GAA activity in cell lines derived from Pompe patients and in transfected cells expressing misfolded forms of GAA. … It is a small molecule designed to act as a pharmacological chaperone that specifically binds, stabilizes, and facilitates the proper folding and trafficking of α-glucosidase (GAA).
SRP 299
go.drugbank.com/drugs/DB05440ExperimentalSRP 299 is a preparation of killed Mycobacterium vaccae that has been tested in uses related to inhibiting periodontal disease, in treating asthma and in treating eczema, itching and inflammation. … Mycobacterium vaccae is a non-pathogenic, saprophytic bacteria whose antigens can be used to induce peripheral immune activation through the activity of regulatory T-cells that surpress inappropriate Th2
Medetomidine
go.drugbank.com/drugs/DB11428ExperimentalVet approvedMedetomidine is an intravenously available alpha-2 adrenergic agonist. The drug has been developed by Orion Pharma. … Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride.
Synonyms: (±)-4-(α,2,3-trimethylbenzyl)imidazoleCategories: Adrenergic alpha-2 Receptor Agonists, Heterocyclic Compounds, 1-RingStabilin-1
go.drugbank.com/bio_entities/BE0010944TargetHumansActs as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection.
Synonyms: Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1Maxy-G34
go.drugbank.com/drugs/DB05718Investigationallysines have been removed as compared to wild type human G-CSF to avoid PEGylation of such sites. … This variant contains multiple non-naturally occurring lysines that have been introduced into alpha helixes of wild type human G-CSF as PEGylation sites, and from which multiple undesired, naturally occurring
Categories: Compounds used in a research, industrial, or household settingCenegermin
go.drugbank.com/drugs/DB13926ApprovedInvestigationalThe prevalence of neurotrophic keratitis has been estimated to be less than five in 10,000 individuals. … Cenegermin received approval from the US FDA a year later in August of 2018. [L4563] Neurotrophic keratitis is a degenerative disease resulting from a loss of corneal sensation.
Pitolisant
go.drugbank.com/drugs/DB11642ApprovedInvestigationalnot been established with pitolisant. … Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy.
Categories: Histamine-3 Receptor Antagonist/Inverse Agonist, Histamine-3 (H3) Receptor Antagonists/Inverse AgonistsSodium-dependent phosphate transporter 2
go.drugbank.com/bio_entities/BE0008680TransporterHumansSodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, P...
Synonyms: Gibbon ape leukemia virus receptor 2Function: signaling receptor activity