Maxy-G34

Identification

Generic Name: Maxy-G34
DrugBank Accession Number: DB05718
Background: MAXY-G34 is a pegylated variant of human granulocyte-colony stimulating factor (G-CSF). This variant contains multiple non-naturally occurring lysines that have been introduced into alpha helixes of wild type human G-CSF as PEGylation sites, and from which multiple undesired, naturally occurring lysines have been removed as compared to wild type human G-CSF to avoid PEGylation of such sites. Specifically, the amino acid sequence of MAXY-G34 differs from that of human wild type G-CSF at residues 16, 34, 40, 105 and 159. This was accomplished by removing the three lysine residues at positions 16, 34 and 40, and replacing them with arginine, and substituting two new lysine residues at positions 105 and 159. MAXY-G34 is pegylated with 5 kd mPEG SPA (succinimidyl propionate) groups at 3 amino acid residues, including PEG groups attached at the amino terminal end of the protein and at two internal lysine residues, while Neulasta has a single 20 Kd PEG group attached at the N terminal end of the wild type G-CSF protein. It is being developed by Maxygen, Inc. for the treatment of chemotherapy-induced neutropenia.
Type: Biotech
Groups: Investigational
Biologic Classification: Protein Based Therapies
Other protein based therapies
Protein Chemical Formula: Not Available
Protein Average Weight: Not Available
Sequences: Not Available
Synonyms: Not Available

Pharmacology

Indication: Investigated for use/treatment in adverse effects (chemotherapy) and neutropenics.

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Pharmacodynamics: Maxy-G34 is a PEGylated proprietary G-CSF variant designed to be administered as a single subcutaneous injection once per chemotherapy cycle. Maxygen has made changes in the G-CSF gene sequence that code for novel PEGylation sites in the resulting protein. In contrast to the currently marketed PEGylated G-CSF, Maxy-G34 has multiple PEG groups attached at specifically selected sites on the molecule. In several in vivo models, Maxy- G34 has demonstratedimproved pharmacokinetics and pharmacodynamics compared to the currently marketed PEGylated G-CSF.
Mechanism of action: Neutropenia is a severe decrease in neutrophil cell counts in the blood. Neutropenia is a common side effect of chemotherapeutic treatments for many forms of cancer, including breast cancer, lung cancer, lymphomas and leukemias. Neutropenic patients contract bacterial infections more easily and often, some of which can be life threatening. Further, and most importantly, neutropenic patients may receive reduced or delayed chemotherapy treatment, which can result in cancer progression. Maxy-G34, like natural G-CSF is a protein that stimulates the body's bone marrow to produce neutrophils, a specific type of white blood cell that plays an important role in the defense against bacterial infections.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half-life: Not Available
Clearance: Not Available
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Toxicity: Not Available
Pathways: Not Available
Pharmacogenomic Effects/ADRs: Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Cyclophosphamide	The risk or severity of pulmonary toxicity can be increased when Maxy-G34 is combined with Cyclophosphamide.
Vinblastine	The risk or severity of peripheral neuropathy can be increased when Maxy-G34 is combined with Vinblastine.
Vincristine	The risk or severity of peripheral neuropathy can be increased when Maxy-G34 is combined with Vincristine.
Vindesine	The risk or severity of peripheral neuropathy can be increased when Maxy-G34 is combined with Vindesine.
Vinflunine	The risk or severity of peripheral neuropathy can be increased when Maxy-G34 is combined with Vinflunine.

Food Interactions

Not Available

Chemical Identifiers

UNII: Not Available
CAS number: Not Available

References

General References

Not Available

External Links

PubChem Substance: 347910196

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
2	Unknown Status	Treatment	Breast Cancer / Chemotherapy Induced Neutropenia	1

Pharmacoeconomics

Manufacturers: Not Available
Packagers: Not Available
Dosage Forms: Not Available
Prices: Not Available
Patents: Not Available

Properties

State: Liquid
Experimental Properties: Not Available

Drug created at November 18, 2007 18:27 / Updated at June 12, 2020 16:52