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Trimetazidine
go.drugbank.com/drugs/DB09069ApprovedInvestigational[A233215] It is hypothesized that trimetazidine inhibits 3-ketoacyl coenzyme A thiolase, which decreases fatty acid oxidation but not glucose metabolism, preventing the acidic conditions that exacerbate … [A233255,A233260] Acidic conditions, caused by anaerobic metabolism and fatty acid oxidation, in response to myocardial ischemia, activate sodium-hydrogen and sodium-calcium antiport systems.
Products: AXINOL TABLET 20MG, Metazine Tablet 20mgEslicarbazepine acetate
go.drugbank.com/drugs/DB09119ApprovedInvestigationalEslicarbazepine's mechanism of action is not well understood, but it is known that it does exert anticonvulsant activity by inhibiting repeated neuronal firing and stabilizing the inactivated state of
Products: ZEBINIX 400MG TABLET, 7 TABLET, ZEBINIX 400MG TABLET, TABLET, 14 ADETOspemifene
go.drugbank.com/drugs/DB04938ApprovedOspemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.
Synonyms: 2-(4-(4-Chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanolProducts: SENSHIO FILM-COATED TABLET 60MGRacecadotril
go.drugbank.com/drugs/DB11696InvestigationalRacecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
Products: Hidrasec Children 30mg Granules for Oral Suspension, Hidrasec Children Granules for Oral Suspension 30mgVedolizumab
go.drugbank.com/drugs/DB09033ApprovedInvestigational[L48216] Vedolizumab was developed by Takeda and approved by the FDA under the brand name ENTYVIO for the maintenance therapy of moderately to severely active Ulcerative Colitis and Crohn’s Disease … [A261576] Vedolizumab is administered by IV infusion over a period of 30 minutes; after the first dose, it is given again at two and six weeks and then every 8 weeks thereafter.
Products: Entyvio 300mg Powder for Concentrate for Solution for Infusion, ENTYVIO POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 300MG/VIALSilodosin
go.drugbank.com/drugs/DB06207ApprovedInvestigational[A231159] Silodosin was first approved by the FDA in October 2008 [A231159] and it is also approved in Europe and Canada. … [A231159] Silodosin works by binding to α<sub>1A</sub>-adrenoceptors with high affinity and relaxing the lower urinary tract, thereby improving urinary symptoms and alleviating bladder outlet obstruction
Products: UROREC 4MG, SILBESAN 4MG HKPAgalsidase beta
go.drugbank.com/drugs/DB00103ApprovedInvestigationalAgalsidase beta is a recombinant human α-galactosidase A similar to agalsidase alfa. While patients generally do not experience a clinically significant difference in outcomes between the two drugs, some patients may experience greater b...
Products: FABRAZYME 35MG INJECTION, 35mg (agalsidase beta)Biperiden
go.drugbank.com/drugs/DB00810ApprovedInvestigationalWithdrawnIt has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.
Products: AKINETON 4MG, AKINETON 4MG RETARDSildenafil
go.drugbank.com/drugs/DB00203ApprovedInvestigationalNevertheless, it is because of this mechanism that sildenafil is also indicated for treating pulmonary arterial hypertension but is also additionally notorious for interacting with various anti-anginal … In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850
Products: VIATHER BY CORNE, REVATIO 20MGMethsuximide
go.drugbank.com/drugs/DB05246ApprovedIt is sold by Pfizer under the name Petinutin.
Products: Celontin Cap 300mg