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Displaying results 4531 - 4540 of 7186 in total
  1. Drug

    Amitriptylinoxide

    go.drugbank.com/drugs/DB13114
    ApprovedWithdrawn

    Amitriptylinoxide has been used in trials studying Major Depression.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
  2. Drug

    Dichlorvos

    go.drugbank.com/drugs/DB11397
    ExperimentalVet approved

    Dichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the _organophosphate_ class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products from … Dichlorvos is found in urban waterways and its toxicity may impact humans, leading to poisoning, neurotoxicity, and cancer.

  3. Drug

    Calcimycin

    go.drugbank.com/drugs/DB19408
    Investigational

    Calcimycin is an ionophore and polyether antibiotic derived from Streptomyces chartreusensis. … It binds to and transports calcium and other divalent cations across membranes, disrupts oxidative phosphorylation, and inhibits ATPase in rat liver mitochondria.

  4. Drug

    OP-145

    go.drugbank.com/drugs/DB05672
    Experimental

    OP-145 is a synthetic antimicrobial peptide developed from human cathelicidin LL-37.

  5. Drug

    Brefeldin A

    go.drugbank.com/drugs/DB07348
    Experimental

    A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.

  6. Drug

    XL844

    go.drugbank.com/drugs/DB05149
    Investigational

    XL844 is a potent inhibitor of the checkpoint kinases CHK1 and CHK2, which induce cell cycle arrest in response to a variety of DNA damaging agents.

  7. Drug

    Nafarelin

    go.drugbank.com/drugs/DB00666
    ApprovedInvestigational

    Nafarelin is a potent synthetic agonist of gonadotropin-releasing hormone with 3-(2-naphthyl)-D-alanine substitution at residue 6. Nafarelin has been used in the treatments of central precocious puberty and endometriosis.

  8. Drug

    R673

    go.drugbank.com/drugs/DB05466
    Experimental

    The phase II program for treatment of depression and anxiety is ongoing in the US and EU.It is not clear how tachykinin antagonists exert their effect, but SP levels have been commonly linked to the functioning … of limbic system with respect to anxiety and depression.

  9. Drug

    MPI-674

    go.drugbank.com/drugs/DB05749
    Experimental

    AIs are a class of drugs that reduce the amount of estrogen circulating in the body by binding to and inhibiting the enzyme aromatase, which is responsible for converting certain hormones to estrogen. … It is developed for the treatment of several serious women’s health conditions including endometrial thinning prior to endometrial ablations in premenopausal women with abnormal uterine bleeding (AUB).

  10. Drug

    CGC-11047

    go.drugbank.com/drugs/DB05722
    Investigational

    CGC-11047 is a polyamine analog designed to halt cell growth and induce apoptosis.