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CEP-1347
go.drugbank.com/drugs/DB05403InvestigationalCEP-1347 is a semi-synthetic compound shown to protect multiple nerve cell types from a variety of insults leading to programmed cell death (apoptosis) which could improve the survival of dopamine neurons
Categories: Heterocyclic Compounds, 2-Ring, Heterocyclic Compounds, 3-RingBizelesin
go.drugbank.com/drugs/DB12352InvestigationalBizelesin has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingKOS-2187
go.drugbank.com/drugs/DB05946ExperimentalKOS-2187, a novel erythromycin-based motilin agonist, or motilide, as a clinical candidate for the treatment of gastrointestinal motility disorders such as gastroparesis and gastroesophageal reflux disease
Synonyms: (3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-7,10,12,13-tetrahydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-6-[3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl, -14-phenyl-oxacyclotetradecan-2-oneTacrine
go.drugbank.com/drugs/DB00382ApprovedWithdrawnA centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: 1,2,3,4-tetrahydro-9-acridinamine, 1,2,3,4-tetrahydro-9-aminoacridineRupintrivir
go.drugbank.com/drugs/DB05102ExperimentalRupintrivir was active against all 48 HRV serotypes tested in a cell protection assay in H1-HeLa cells. It is designed to combat colds caused by rhinovirus. … Rupintrivir is a rhinovirus 3C protease inhibitor in development for use against human rhinoviral (HRV) infections.
Categories: Heterocyclic Compounds, 1-RingNisin Z
go.drugbank.com/drugs/DB19122InvestigationalNisin Z is under investigation in clinical trial NCT06097468 (Nisin in Oral Cavity Squamous Cell Carcinoma (OCSCC)).
Categories: Compounds used in a research, industrial, or household settingSynonyms: Nisin a, 27-l-asparagine-, Nisin ZGR270773
go.drugbank.com/drugs/DB06427InvestigationalNCT00089986 (completed with results, treatment of suspected or confirmed gram-negative severe sepsis in adults, comparing GR270773 with a placebo). … GR270773, was investigated in two clinical trials for its potential to treat sepsis: NCT00158769 (completed, comparing the effects of infusion between healthy adults and those with damaged livers) and
Gacyclidine
go.drugbank.com/drugs/DB13096InvestigationalGacyclidine has been used in trials studying the treatment of Tinnitus.
Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingBiricodar
go.drugbank.com/drugs/DB04851InvestigationalThe pipecolinate derivative biricodar (VX-710) is a clinically applicable modulator of P-glycoprotein (Pgp) and multidrug resistance protein (MRP-1).
Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 1-RingKB3305
go.drugbank.com/drugs/DB06349ExperimentalKB3305 is an investigational liver selective antagonist for the glucocorticoid receptor, developed by Karo Bio for the treatment of Type 2 Diabetes.
Synonyms: (4R)-4-((3S,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-DIHYDROXY-3-(2-(4-((8S,11R,13S,14S,17S)-17-HYDROXY-13-METHYL-3-OXO-17-PROP-1-YNYL-1,2,6,7,8,11,12,14,15,16-DECAHYDROCYCLOPENTA(A)PHENANTHREN-11-YL)-N-METHYL-ANILINO, 3.BETA.,5.BETA.,7.ALPHA.,12.ALPHA.)-7,12-DIHYDROXY-3-(2-((4-((11.BETA.,17.BETA.)-17-HYDROXY-3-OXO-17-(1-PROPYN-1-YL)ESTRA-4,9-DIEN-11-YL)PHENYL)METHYLAMINO)ETHOXY)CHOLAN-24-OIC ACID