Rupintrivir

DB05102ExperimentalSmall molecule

Rupintrivir is a rhinovirus 3C protease inhibitor in development for use against human rhinoviral (HRV) infections. Rupintrivir was active against all 48 HRV serotypes tested in a cell protection assay... It is designed to combat colds caused by rhinovirus.

Mechanism: The 3C protease (3CP) enzyme is central to rhinovirus replication. By binding to and inhibiting this enzyme, AG7088 prevents rhinovirus replication in cells of the respiratory tract and stops cold symptoms developing.
Curator reviewed
Primary indication: Investigated for use/treatment in viral infection.Curator reviewed
Formula / weight: C₃₁H₃₉FN₄O₇ · 598.6624 g/mol (avg)
Code names: AG-7088

Resolves to

Compound

UNIIRGE5K1Q5QWCAS223537-30-2ChEMBLCHEMBL20210PubChem6440352

Structure

InChIKeyCAYJBRBGZBCZKO-BHGBQCOSSA-NSMILESCCOC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@@H](CC(=O)[C@H](C(C)C)NC(=O)C1=NOC(C)=C1)CC1=CC=C(F)C=C1

Targets

P04936Genome polyproteinP03303Genome polyprotein

What you can answer from here — as of March 06, 2025

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

14Drug interactionsStructured to mechanism, not free text

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Rupintrivir, and which of those have an active Phase 3 trial?

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