Search
Celiprolol
go.drugbank.com/drugs/DB04846ApprovedInvestigationalWithdrawnIt is simultaneously a selective β1 receptor antagonist, a β2 receptor partial agonist and a weak α2 receptor antagonist. … Celiprolol is not approved for use by the FDA in the treatment of vascular Ehlers–Danlos syndrome.
Categories: Adrenergic beta-2 Receptor Agonists, Adrenergic beta-3 Receptor AgonistsElacytarabine
go.drugbank.com/drugs/DB05494InvestigationalElacytarabine is a fatty acid derivative of [cytarabine], an approved cytotoxic cancer drug. Cytarabine has limitations such as minimal uptake in solid tumours and is only used to treat leukaemia. … Elacytarabine is designed to overcome this limitation and has shown considerable uptake in solid tumour cells.
Flosequinan
go.drugbank.com/drugs/DB13228ApprovedWithdrawnFlosequinan was approved in the USA and the UK for a year prior to being withdrawn from the market due to increased mortality in chronic heart failure patients, found in drug trials.[A174979,L43942]
Categories: Vasodilators Used in Cardiac DiseasesRibosome-binding protein 1
go.drugbank.com/bio_entities/BE0003466TargetHumansActs as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane
Synonyms: Ribosome receptor protein, 180 kDa ribosome receptor homologNatural killer cells antigen CD94
go.drugbank.com/bio_entities/BE0010559TargetHumansImmune receptor involved in self-nonself discrimination.
Synonyms: NK cell receptor, Killer cell lectin-like receptor subfamily D member 1Function: HLA-A specific activating MHC class I receptor activityVusolimogene oderparepvec
go.drugbank.com/drugs/DB23008ApprovedInvestigationalkilling and GM-CSF promoting dendritic cell and monocyte activation to drive an anti-tumor immune response. … [L64061,L64062] It is the second oncolytic viral therapy approved in the United States, following talimogene laherparepvec (T-VEC, Imlygic) in 2015, and the first approved for melanoma that has progressed
AVI-4557
go.drugbank.com/drugs/DB05447Experimentalin clearance and an increase in maximal blood concentration (Cmax). … AVI-4557 is an oral antisense compound that selectively inhibits the metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown of approximately half of currently
V-type immunoglobulin domain-containing suppressor of T-cell activation
go.drugbank.com/bio_entities/BE0010797TargetHumansImmunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity).
Synonyms: Platelet receptor Gi24, V-set immunoregulatory receptorPhenylmercuric acetate
go.drugbank.com/drugs/DB17044ExperimentalPhenylmercuric acetate is an organomercurial compound used as a fungicide and slimicide.[A253082]
Categories: Compounds used in a research, industrial, or household settingCyclizine
go.drugbank.com/drugs/DB01176ApprovedWithdrawnA histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)