Search
Debrisoquine
go.drugbank.com/drugs/DB04840ApprovedIt is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. … They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesFlunarizine
go.drugbank.com/drugs/DB04841ApprovedInvestigationalFlunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. … It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazineRoxadustat
go.drugbank.com/drugs/DB04847ApprovedInvestigationalRoxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. … [A245393] Roxadustat was first approved by the European Commission in August 2021.[L40323]
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingZanapezil
go.drugbank.com/drugs/DB04859ExperimentalZanapezil (TAK-147) is a selective acetylcholine (ACh) esterase inhibitor under investigation as a drug for Alzheimer's disease (AD) treatment.
Categories: Heterocyclic Compounds, 2-RingIsatoribine
go.drugbank.com/drugs/DB04860ExperimentalIsatoribine is a selective agonist of TLR7.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 7-Deaza-7-thia-8-oxoguanosine, 7-Thia-8-oxoguanosineNebivolol
go.drugbank.com/drugs/DB04861ApprovedInvestigationalNebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. … [A182579] Nebivolol and other beta blockers are generally not first line therapies as many patients are first treated with thiazide diuretics.
Mixtures: AMLONEB 5 MG/5 MG TABLET, 30 ADET, AMLONEB 5 MG/5 MG TABLET, 90 ADETCategories: Cytochrome P-450 Substrates, Adrenergic beta-1 Receptor AgonistsMerimepodib
go.drugbank.com/drugs/DB04862InvestigationalMerimepodib (VX-497) is a novel noncompetitive inhibitor of IMPDH. … Merimepodib is orally bioavailable and inhibits the proliferation of primary human, mouse, rat, and dog lymphocytes at concentrations of approximately 100 nM.
Huperzine A
go.drugbank.com/drugs/DB04864ApprovedInvestigationalWithdrawnHuperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss _Huperzia serrata_. … It is currently being investigated as a possible treatment for diseases characterized by neurodegeneration – particularly Alzheimer’s disease.
Categories: Compounds used in a research, industrial, or household settingSynonyms: L-huperzine A, Huperzine AHalofuginone
go.drugbank.com/drugs/DB04866InvestigationalVet approvedHalofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. … Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and received orphan drug designation from the U.S. Food and Drug Administration in March, 2000.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: (+/-)-trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinoneOleoyl-estrone
go.drugbank.com/drugs/DB04870InvestigationalOleoyl-estrone (OE) is a fatty acid ester of estrone. This hormone occurs naturally and is found circulating in various animal species and humans. … Body protein loss is an unpleasant effect of fat loss by the restriction of calories, and studies show that this drug appears to avoid this effect.
Synonyms: Estrone 3-oleate