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Revumenib
go.drugbank.com/drugs/DB18515ApprovedInvestigationalAbnormal gene rearrangements at chromosome locus 11q23, called KMT2A rearrangements or translocations, are present in 5%-10% of patients with acute leukemias and are the sole genetic aberration found in … [L51888] In October of 20225, it was approved for myeloid leukemia patients with nucleophosmin 1 (NPM1) mutations. [L54376]
Synonyms: Benzamide, n-ethyl-2-((4-(7-((trans-4-((ethylsulfonyl)amino)cyclohexyl)methyl)-2,7-diazaspiro(3.5)non-2-yl)-5-pyrimidinyl)oxy)-5-fluoro-n-(1-methylethyl)-NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
go.drugbank.com/bio_entities/BE0000081TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Synonyms: Complex I-42kDCalnexin
go.drugbank.com/bio_entities/BE0001011TargetHumansAssociated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation.
Synonyms: Major histocompatibility complex class I antigen-binding protein p88De Novo Triacylglycerol Biosynthesis TG(20:0/20:1(11Z)/20:5(5Z,8Z,11Z,14Z,17Z))
smpdb.ca/view/SMP0019131MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(20:0/20:2(11Z,14Z)/20:4(5Z,8Z,11Z,14Z))
smpdb.ca/view/SMP0033811MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(20:0/20:2(11Z,14Z)/20:4(8Z,11Z,14Z,17Z))
smpdb.ca/view/SMP0033812MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(20:0/20:3(5Z,8Z,11Z)/20:3(8Z,11Z,14Z))
smpdb.ca/view/SMP0033824MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(20:0/20:3(8Z,11Z,14Z)/20:3(5Z,8Z,11Z))
smpdb.ca/view/SMP0033836MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(20:1(11Z)/20:2(11Z,14Z)/20:3(5Z,8Z,11Z))
smpdb.ca/view/SMP0034452MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(20:1(11Z)/20:3(5Z,8Z,11Z)/20:2(11Z,14Z))
smpdb.ca/view/SMP0034464MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...