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Bisoxatin
go.drugbank.com/drugs/DB09219ApprovedBisoxatin is a stimulant laxative which increases peristalsis and inhibits absorbtion of water and ions in the intestine [L926]. … It is marketed in Belgium under the tradename Wylaxine and used for the treatment of constipation and for preparation of the colon for surgical procedures.
Categories: Alimentary Tract and MetabolismNiflumic acid
go.drugbank.com/drugs/DB04552InvestigationalNiflumic acid is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
Categories: Niflumic Acid and Prodrugs, Antiinflammatory and Antirheumatic ProductsSerelaxin
go.drugbank.com/drugs/DB05794Investigationalbones come together).It is a heterodimer protein secreted by the corpus luteum and placenta during pregnancy. … Recombinant human relaxin is a hormone produced during pregnancy that facilitates the birth process by causing a softening and lengthening of the cervix and the pubic symphysis (the place where the pubic
Categories: Vasodilators Used in Cardiac DiseasesGlucagon
go.drugbank.com/drugs/DB00040ApprovedInvestigationalGlucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia. … [L7634,L7637,L7640,L7643,L8519] Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and the release of glucose.
Categories: Sex Hormones and Insulins, Amino Acids, Peptides, and ProteinsProducts: GlucaGen 1 mg/ml - Pulver und Lösungsmittel zur Herstellung einer Injektionslösung, GlucaGen HypoKit 1 mg/ml - Pulver und Lösungsmittel zur Herstellung einer InjektionslösungIbudilast
go.drugbank.com/drugs/DB05266InvestigationalIbudilast is currently in development in the U.S. (codes: AV-411 or MN-166), but is approved for use as an antiinflammatory in Japan. … Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume
Polistes metricus venom protein
go.drugbank.com/drugs/DB11029ApprovedPolistes metricus venom protein is an extract of Polistes metricus venom. Polistes metricus venom protein is used in allergenic testing.
Categories: Bee and Wasp VenomXL019
go.drugbank.com/drugs/DB05243InvestigationalXL019 is a selective inhibitor of the cytoplasmic tyrosine kinase JAK2. An IND for XL019 was filed by Exelixis in May 2007.
Serine/threonine-protein kinase mTOR
go.drugbank.com/bio_entities/BE0002386TargetHumansof the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex ( … In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed
Synonyms: Rapamycin and FKBP12 target 1Aleglitazar
go.drugbank.com/drugs/DB08915InvestigationalAleglitazar is an investigational drug from the company Hoffmann–La Roche and is currently in a phase III clinical trial called ALECARDIO. … Aleglitazar is an agonist at the peroxisome proliferator-activated receptor (PPAR) for both the PPARα and PPARγ receptor subtypes.
Queuine
go.drugbank.com/drugs/DB14732ExperimentalNutraceuticalAll eukaryotic organisms, including humans, transform queuine to queuosine by placing it in the wobble position (anticodon) of several tRNAs including aspartic acid, asparagine, histidine, and tyrosine … Quantities of queuine have been found in tomatoes, wheat, coconut water, and milk from humans, cows, and goats. Humans salvage and recover queuine from either ingested food or the gut flora.