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Displaying results 4681 - 4690 of 10000 in total
  1. Drug

    Agmatine

    go.drugbank.com/drugs/DB08838
    Experimental

    Agmantine is a natural metabolite of the amino acid arginine. … It is formed when arginine is decarboxylated by the enzyme arginine decarboxylase and is found naturally in ragweed pollen, ergot fungi, octopus muscle, herring sperm, sponges, and the mammalian brain.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 1-amino-4-guanidobutane, N-(4-aminobutyl)guanidine
  2. Drug

    Pentagastrin

    go.drugbank.com/drugs/DB00183
    Approved

    A synthetic pentapeptide that mimics the actions of endogenous gastrin when given parenterally. It works by stimulating the secretion of gastric acid, pepsin, and intrinsic factor. … It has also been used as a diagnostic aid.

  3. Drug

    AVI-4557

    go.drugbank.com/drugs/DB05447
    Experimental

    AVI-4557 is an oral antisense compound that selectively inhibits the metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown of approximately half of currently … Studies indicate that AVI-4557 can successfully reduce the rate of metabolism for certain drugs, therefore allowing greater and longer availability of the drug in the patient's system through a decrease

  4. Drug

    Allisartan isoproxil

    go.drugbank.com/drugs/DB18880
    Investigational

    Allisartan isoproxil is under investigation in clinical trial NCT03264352 (Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes).

    Categories: Agents Acting on the Renin-Angiotensin System, Heterocyclic Compounds, 1-RingSynonyms: 1H-IMIDAZOLE-5-CARBOXYLIC ACID, 2-BUTYL-4-CHLORO-1-((2'-(2H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL)METHYL)-, (((1-METHYLETHOXY)CARBONYL)OXY)METHYL ESTER
  5. Drug

    Tirapazamine

    go.drugbank.com/drugs/DB04858
    Investigational

    It is important to take into consideration that normally, the cells in these hypoxic regions are resistant to radiotherapy and most anticancer drugs. … For all these reasons, the combination of tirapazamine with other anticancer treatments is highly recommended.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: 1,2,4-benzotriazin-3-amine, 1,4-dioxide, 3-Amino-1,2,4-benzotriazine 1,4-dioxide
  6. Drug

    INO-4800

    go.drugbank.com/drugs/DB15693
    Investigational

    INO-4800 is a DNA vaccine containing the full sequence for the SARS-CoV-2 Spike (S) protein in development for immunization against COVID-19. … [A214475] Early _in vitro_ studies using HEK-293T cells demonstrated that the transfection of INO-4800 results in the expression of S protein by human cells.

  7. Drug

    LCP-AtorFen

    go.drugbank.com/drugs/DB05769
    Investigational

    LCP-AtorFen is a fixed-dose combination therapy for the treatment of high cholesterol levels combining atorvastatin (the active ingredient of Lipitor®) and the lowest dose of fenofibrate without food effect … (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglycerides (TG).

  8. Drug

    Altropane

    go.drugbank.com/drugs/DB04947
    Investigational

    Boston Life Sciences (BLS) is developing Altropane as a potential radio-imaging agent to be used with single photon emission tomography (SPECT), for the early diagnosis of Parkinson's disease (PD) and

  9. Drug

    Ritanserin

    go.drugbank.com/drugs/DB12693
    Investigational

    Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Heterocyclic Compounds, 1-Ring
  10. Drug

    Doxapram

    go.drugbank.com/drugs/DB00561
    ApprovedInvestigationalVet approved

    A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone