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Hu-rhEGF-rP64k/Mont

Hu-rhEGF-rP64k/Mont is a therapeutic vaccine composed by an antigen (recombinant human EGF (rhEGF) chemically conjugated to recombinant P64K (rP64K)) and an adjuvant (Montanide ISA51VG) being investigated

Zinc phenolsulfonate

VPM1002

This vaccine’s urease C gene is replaced with the listeriolysin O encoding gene from Listeria monocytogenes. … By reducing urease C, phagosome acidification can occur, promoting phagolysosome fusion while also providing the optimal low pH for listeriolysin O stability.

AV-COVID-19

The monocytes are then differentiated in vitro into dendritic cells with IL-4 and GM-CSF, incubated with SARS-CoV-2 antigens prior to administration. … AV-COVID-19 is a vaccine composed of autologous dendritic cells loaded with SARS-CoV-2 antigens and with or without Granulocyte-macrophage colony-stimulating factor (GM-CSF).

SCB-2019

SCB-2019 is a recombinant trimeric S protein subunit vaccine candidate being investigated against COVID-19. … As of June 2020, the company is pursuing a randomized, double blind, placebo controlled study (NCT04405908) to test the safety and immunogenicity of the vaccine.

CoronaVac

It was developed by propagating the SARS-CoV-2 CN2 strain inside Vero Cells and inactivating it with B-propiolactone[A219481;A219758]. … CoronaVac, previously known as PiCoVacc, is a SARS-CoV-2 purified, inactivated, and adsorbed vaccine candidate developed by SinoVac Biotech Corporation[A219758].

BBIBP-CorV

BBIBP-CorV vaccine contains a SARS-CoV-2 strain inactivated inside Vero Cells. … Investigation shows this vaccine induces neutralizing antibodies in several mammalian species while also showing protective efficacy with SARS-CoV-2 challenge in rhesus macaques[A219763].

CIGB-258 peptide

CIGB-258 is a peptide that is immunoregulatory and derived from heat shock protein 60 of the cellular variant.

Covid-19 Coronavirus Artificial Antigen Presenting Cell Vaccine

Through analysis of potential immunogenic targets of the SARS-Cov2 genome, a synthetic ‘minigene’ was developed using domains of viral structural proteins and a polyprotein protease. … Spike protein to an ACEII receptor, and with the described approach, the vaccine uses these engineered minigenes to express viral proteins, modify artificial antigen presenting cells (aAPC), and activate T-cells

COVID19 s-vax loaded autologous dendritic cell vaccine

The rationale is that loading a DC cell with SARS-Cov-2 antigens and administering it as a vaccine can induce a more prolific immune response. … These cells are then loaded with antigens produced by a virus or tumor cell and administered as a vaccine.