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Erdosteine
go.drugbank.com/drugs/DB05057ApprovedInvestigationalCo-administration of erdosteine and amoxicillin in patients with acute infective exacerbation of chronic bronchitis resulted in higher concentrations of the antibiotic in the sputum, leading to earlier … It is a _thiol_ derivative produced for the clinical management of chronic obstructive bronchitis, in addition to infective exacerbations of chronic bronchitis.
Categories: Heterocyclic Compounds, 1-RingProducts: DOSTEIN® CAPSULAS, DOSTEIN® SUSPENSIONButalbital
go.drugbank.com/drugs/DB00241ApprovedIllicitThere have not been clinical trials that evaluate the clinical efficacy of butalbital in migraines [A177754] thus it is not indicated for such condition. … Due to these risks, the use of butalbital-containing combination products is typically limited for use only in cases where other medications are deemed ineffective and such usage is advised to be carefully
Mixtures: Fiorinal-C 1/4, Fiorinal-C 1/2Categories: combinations of barbiturates, Cytochrome P-450 CYP3A InducersMitochondrial amidoxime reducing component 2
go.drugbank.com/bio_entities/BE0017987EnzymeHumansMay be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). … Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752).
Synonyms: MARC2Metrizoic acid
go.drugbank.com/drugs/DB09346ApprovedIn general, the drug was well tolerated by patients during cardiac examinations [A32091]. … Metrizoic acid is a molecule used as a contrast medium. It present a higher risk of allergic reactions due to its high osmolality. Its approval has been discontinued by the FDA.
Categories: Compounds used in a research, industrial, or household setting, Diagnostic Uses of ChemicalsOdevixibat
go.drugbank.com/drugs/DB16261ApprovedInvestigationalOdevixibat, or A4250, is an ileal sodium/bile acid cotransporter inhibitor indicated for the treatment of pruritus in patients older than 3 months, with progressive familial intrahepatic cholestasis (PFIC … [A236808] Odevixibat was granted FDA and Health Canada approval on 20 July 2021 and 13 November 2023 respectively.[L34793,L49535]
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 2-RingPoractant alfa
go.drugbank.com/drugs/DB09113ApprovedInvestigationalPoractant alfa is a creamy white suspension of this extract in 0.9% sodium chloride solution. It contains no preservatives. … Poractant alfa is a pulmonary surfactant marketed as Curosurf in the United States and Canada.
Products: CUROSURF ® 3.0 ML, CUROSURF 240 MG/3 ML INTRATRAKEAL SUSPANSIYON IÇEREN FLAKON, 1 ADETTenofovir
go.drugbank.com/drugs/DB14126Investigational[A37693] The antiviral activities of tenofovir were first reported in 1993 and this agent was commercially available since 2008 in the form of [tenofovir disoproxil] and [tenofovir alafenamide] in order … [A37693] In the most strict sense and due to the fact that it presents a phosphate group bound to the nitrogenous base, it is determined as an actual nucleotide analog.
Synonyms: (R)-PMPACategories: P-glycoprotein substrates, Heterocyclic Compounds, 2-RingPhenoxyethanol
go.drugbank.com/drugs/DB11304ApprovedInvestigationalPhenoxyethanol (EU), or PE, is the most commonly used globally-approved preservative in personal care formulations. It is very easy to use in various types of formulations and is chemically stable. … It has also been used in vaccines and shown to inactivate bacteria, and several types of yeast [A32838].
Mixtures: Linola sept 1 mg/g + 10 mg/g Wund-Gel, HydroGold 9Synonyms: 1-Hydroxy-2-phenoxyethane, 2-phenoxyethanolMitochondrial amidoxime-reducing component 1
go.drugbank.com/bio_entities/BE0015448EnzymeHumansMay be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). … Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129
Synonyms: MARC1Acitretin
go.drugbank.com/drugs/DB00459ApprovedInvestigationalAn oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Categories: Retinoids for Treatment of PsoriasisSynonyms: (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid, all-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid