Acitretin

DB00459ApprovedInvestigationalSmall moleculeRetinoids

Acitretin is an oral retinoid used in the treatment of severe psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.

Mechanism: The mechanism of action of acitretin is unknown, however it is believed to work by targeting specific receptors (retinoid receptors such as RXR and RAR) in the skin which help normalize the growth cycle of skin cells.
Curator reviewed
Primary indication: For the treatment of severe psoriasis in adults.Curator reviewed · 2 structured indications
Formula / weight: C₂₁H₂₆O₃ · 326.4293 g/mol (avg)
First approval: Canada, 2017 · United States, 1996
Also known as: Etretin
Code names: RO 10-1670 · RO 10-1670/000
Brand names: Soriatane

Resolves to

Compound

UNIILCH760E9T7CAS55079-83-9ChEMBLCHEMBL1131ChEBI50173PubChem5284513KEGGD02754

Clinical / RWD

RxNorm16818ATCD05BB02PharmGKBPA448039

Structure

InChIKeyIHUNBGSDBOWDMA-AQFIFDHZSA-NSMILESCOC1=C(C)C(C)=C(\C=C\C(\C)=C\C=C\C(\C)=C\C(O)=O)C(C)=C1

Targets

P19793RXRAP10276RARAP10826RARBP13631RARGP48443RXRGP28702RXRBP40763STAT3P09455RBP1

What you can answer from here — as of September 13, 2026

9Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

599Drug interactionsStructured to mechanism, not free text

31Clinical trialsPhase, status and sponsor resolved per trial

2Structured indicationsCondition, population, route and combination as fields, not prose

2ContraindicationsEach with its own population and attribute set

83Marketed productsAcross 9 countries and 28 labellers

1ATC codeIncluding every combination product, plus 21 drug categories

17+ReferencesStructured and connected to the statements they support

Which drugs share a target with Acitretin, and which of those have an active Phase 3 trial?

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