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Displaying results 4731 - 4740 of 10000 in total
  1. Drug

    Tovinontrine

    go.drugbank.com/drugs/DB16193
    Investigational

    Tovinontrine is an orally administered, highly selective phosphodiesterase 9 (PDE9) small molecule inhibitor. … Tovinontrine is under investigation in clinical trial NCT04474314 (A Study of IMR-687 in Subjects With Sickle Cell Disease).

    Synonyms: 6-((3S,4S)-4-METHYL-1-(2-PYRIMIDINYLMETHYL)-3-PYRROLIDINYL)-3-(TETRAHYDRO-2H-PYRAN-4-YL)IMIDAZO(1,5-A)PYRAZIN-8(7H)-ONE, 6-[(3S,4S-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imadazo[1,5-a]pyrazin-8-one
  2. Drug

    Sisomicin

    go.drugbank.com/drugs/DB12604
    Investigational

    Sisomicin has been used in trials studying the treatment of Pyoderma.

    Synonyms: (2S-CIS)-4-O-(3-AMINO-6-(AMINOMETHYL)-3,4-DIHYDRO-2H-PYRAN-2-YL)-2-DEOXY-6-O-(3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-.BETA.-L-ARABINOPYRANOSYL)-D-STREPTAMINE, 2-DEOXY-4-O-(3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-.BETA.-L-ARABINOPYRANOSYL)-6-O-(2,6-DIAMINO-2,3,4,6-TETRADEOXY-.ALPHA.-D-GLYCERO-HEX-4-ENOPYRANOSYL)-L-STREPTAMINECategories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index
  3. Drug

    Irsenontrine

    go.drugbank.com/drugs/DB19044
    Investigational

    Irsenontrine is under investigation in clinical trial NCT03467152 (Study to Evaluate the Efficacy, Safety and Tolerability of E2027 (Hereinafter Referred to as Irsenontrine) in Participants With Dementia With Lewy Bodies).

    Synonyms: 4h-pyrazolo(4,3-c)quinolin-4-one, 1,5-dihydro-7-(2-methoxy-3,5-dimethyl-4- pyridinyl)-1-((3s)-tetrahydro-3-furanyl)-, 7-(2-methoxy-3,5-dimethylpyridin-4-yl)-1-((3s)-tetrahydrofuran-3-yl)-1,5-dihydro-4h-pyrazolo(4,3-c)quinolin-4-one
  4. Drug

    TTI-101

    go.drugbank.com/drugs/DB17578
    Investigational

    Synonyms: Benzenesulfonamide, n-(1',2-dihydroxy(1,2'-binaphthalen)-4'-yl)-4-methoxy-, Stat3 inhibitor c188-9
  5. Drug

    Atpenin A5

    go.drugbank.com/drugs/DB04631
    Experimental

    Synonyms: 3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone, Atpenin A5Categories: Heterocyclic Compounds, 1-Ring
  6. Drug

    Oxfenicine

    go.drugbank.com/drugs/DB04291
    Experimental

    Oxfenicine in an inhibitor of myocardial metabolism of nonesterified fatty acids (NEFA).

    Synonyms: L-2-(p-hydroxyphenyl)glycine, L-4-hydroxyphenylglycineCategories: Carnitine O-Palmitoyltransferase, antagonists & inhibitors
  7. Drug

    Lamotrigine

    go.drugbank.com/drugs/DB00555
    ApprovedInvestigational

    It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. … Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 countries.

    Synonyms: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazineInternational brands: Lameptil S
  8. Drug

    Ondansetron

    go.drugbank.com/drugs/DB00904
    ApprovedInvestigationalWithdrawn

    [L5221] The FDA withdrew its approval for the use of all intravenous drug products containing more than 16 mg of ondansetron hydrochloride in a single dose, due to a high risk of QT prolongation. … A competitive serotonin type 3 receptor antagonist.

    Categories: Serotonin 5-HT3 Receptor Antagonists, Antiemetic Serotonin 5-HT3 Receptor AntagonistsProducts: VONAU FLASH® 8 MG TABLETA DE DESINTEGRACION ORAL, VONAU FLASH® 4 MG TABLETA DE DESINTEGRACION ORAL
  9. Drug

    Etizolam

    go.drugbank.com/drugs/DB09166
    Investigational

    Etizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. … It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.

    Synonyms: 4-(o-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno(3,2-f)-s-triazolo(4,3-a)(1,4)diazepineCategories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 Substrates
  10. Drug

    Granisetron

    go.drugbank.com/drugs/DB00889
    ApprovedInvestigational

    A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.

    Categories: Heterocyclic Compounds, 2-Ring, Serotonin 5-HT3 Receptor AntagonistsProducts: GRANI-DENK 1 MG/ ML- AMPOLLA DE 1 ML, KYTRIL 2 MG FİLM KAPLI TABLET, 5 ADET