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Mepolizumab
go.drugbank.com/drugs/DB06612ApprovedInvestigationalEosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm<sup>3</sup> or more) is associated with a spectrum … Mepolizumab was first approved by the FDA on November 4, 2015, as an add-on therapy for severe asthma and marketed under the brand name Nucala by GlaxoSmithKline.
Categories: Interleukin-5 AntagonistProducts: Nucala 40 mg/0,4 mL S.C. Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör (1 adet), Nucala 40 mg/0,4 mL S.C. Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör (3 adet)Ramipril
go.drugbank.com/drugs/DB00178ApprovedInvestigationalRamipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. … Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).
Synonyms: (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acidMixtures: Lasitace 5 mg/40 mg Kapseln, Trinomia 100 mg/40 mg/5 mg HartkapselnMivacurium
go.drugbank.com/drugs/DB01226ApprovedWithdrawnIt binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission. … Mivacurium is a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant.
Categories: Heterocyclic Compounds, 2-RingProducts: MİVACRON 10 MG/5 ML ENJEKSİYONLUK ÇÖZELTİ, 5 ADET, MIVACRON INJECTION 10 mg/5 mlEthanol
go.drugbank.com/drugs/DB00898ApprovedInvestigationalIt is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. … A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant.
Synonyms: 1-HydroxyethaneMixtures: Adventure Medical Kits 1-4 Person First Aid, Nox-A-StingSibutramine
go.drugbank.com/drugs/DB01105ApprovedIllicitWithdrawnIt is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the United States. … In October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: OBESTOP® 10 MG CAPSULAS, OBESTOPPOR 5 MG CAPSULASRasagiline
go.drugbank.com/drugs/DB01367ApprovedInvestigationalRasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.
Synonyms: (R)-N-2-Propynyl-1-indanamine, (1R)-N-propargylindan-1-amineCategories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesFluvoxamine
go.drugbank.com/drugs/DB00176ApprovedInvestigationalFluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. … Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database comprised of approximately 35,000 patients.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: VERLIN TABLETAS X 50 MG, VOXAMIN® TABLETA RECUBIERTALarotrectinib
go.drugbank.com/drugs/DB14723ApprovedInvestigationalLarotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays … an important role in tumor cell growth and survival.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: VITRAKVI®CÁPSULAS DE 100MG, VITRAKVI 20 MG/ML ORAL ÇÖZELTİ, 2x50 MLCaffeine
go.drugbank.com/drugs/DB00201ApprovedInvestigationalCaffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. … [T716] Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection.
Mixtures: GRIPIN 250 MG/15 MG KAPSÜL, 4 KAPSÜL, Re-action ECategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingTrihexyphenidyl
go.drugbank.com/drugs/DB00376ApprovedInvestigational[A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant adverse effects. … [L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity.
International brands: Ea TenCategories: Heterocyclic Compounds, 1-Ring