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Iloperidone
go.drugbank.com/drugs/DB04946ApprovedInvestigationalIloperidone is a benzisoxazole [A263557] and an atypical antipsychotic agent that was first approved by the FDA on May 6, 2009. … [A263547] Iloperidone is currently used to treat schizophrenia and manic or mixed episodes associated with bipolar disorder.[L50527]
LS11
go.drugbank.com/drugs/DB05918InvestigationalLS11(talaporfin sodium) is an agent consisting of chlorin e6, derived from chlorophyll, and L-aspartic acid with photosensitizing activity. … After intratumoral activation by light emitting diodes, taporfin sodium forms an extended high energy conformational state that generates singlet oxygen, resulting in free radical-mediated cell death.
Nirogacestat
go.drugbank.com/drugs/DB12005ApprovedInvestigationaland thus impede the growth of desmoid tumors. … [A262556] Interaction between the notch receptors and their ligands activates proteolytic cleavage by gamma-secretase; therefore, the inhibition of gamma-secretase can potentially inhibit Notch signaling
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsRoxatidine acetate
go.drugbank.com/drugs/DB08806InvestigationalRoxatidine acetate is a specific and competitive H2 receptor antagonist. It is currently approved in South Africa under the tradename Roxit.
Categories: Alimentary Tract and Metabolism, Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord)Dabigatran
go.drugbank.com/drugs/DB14726ApprovedInvestigationalDabigatran is the active form of the orally bioavailable prodrug [dabigatran etexilate].
Seproxetine
go.drugbank.com/drugs/DB06731ExperimentalIt is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an antidepressant but development was never completed and the drug was never marketed.
Nadofaragene firadenovec
go.drugbank.com/drugs/DB17381ApprovedInvestigationalIt is the first gene therapy approved by the FDA for the treatment of bladder cancer.[L44381,L44431] BCG-unresponsive NMIBC has a high recurrence and is notably difficult to treat. … [A255111] Nadofaragene firadenovec is formulated with an excipient (Syn-3) that facilitates gene transfer across the urothelium and promotes the transduction of IFNα2b.
Categories: Cellular and Gene Therapy, Antineoplastic cell and gene therapyTAS-102
go.drugbank.com/drugs/DB08937InvestigationalTipiracil prevents trifluridine from being broken down when taken orally. … It is composed of the thymidine phosphorylase inhibitor (TPI) tipiracil and the cytotoxin trifluridine. Trifluridine inhibits tumor growth by being incorporated into DNA during DNA synthesis.
Categories: Nucleic Acids, Nucleotides, and NucleosidesNemolizumab
go.drugbank.com/drugs/DB15252ApprovedInvestigationalNemolizumab is a humanized monoclonal modified immunoglobulin 2 (IgG2) antibody directed against interleukin-31 receptor alpha (IL-31RA),[L51159] which is an endogenous cytokine implicated in the pathophysiology … [A264254] By binding to IL-31RA, nemolizumab blocks the IL-31 signalling cascades that lead to inflammation.
Categories: Amino Acids, Peptides, and ProteinsEtesevimab
go.drugbank.com/drugs/DB15897Investigational[L40174] The EUA currently allows bamlanivimab and etesevimab for post-exposure prophylaxis of COVID-19 in adults and children.[L40179] … Etesevimab (LY-CoV016, also known as JS016) is a fully human and recombinant monoclonal antibody that targets the SARS-CoV-2 surface spike protein receptor binding domain.
Categories: Amino Acids, Peptides, and Proteins