Seproxetine

DB06731ExperimentalSmall molecule

Seproxetine is also known as (S)-norfluoxetine. It is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an... Seproxetine was being investigated by Eli Lilly as an antidepressant but development was never completed and the drug was never marketed.

Mechanism: Seproxetine is also known as (S)-norfluoxetine. It is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an antidepressant but development was never completed and the drug was never marketed.
Curator reviewed
Formula / weight: C₁₆H₁₆F₃NO · 295.305 g/mol (avg)
Also known as: (S)-norfluoxetine

Resolves to

Compound

UNII25CO3X0R31CAS126924-38-7ChEMBLCHEMBL465123PubChem3058751

Structure

InChIKeyWIQRCHMSJFFONW-HNNXBMFYSA-NSMILESNCC[C@H](OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1

Targets

Q01959SLC6A3P31645SLC6A4P23975SLC6A2

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,597Drug interactionsStructured to mechanism, not free text

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with Seproxetine, and which of those have an active Phase 3 trial?

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