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Cantharidin
go.drugbank.com/drugs/DB12328ApprovedInvestigational[L47496] The approval was based on positive results from 2 phase III trials, CAMP-1 and CAMP-2, where 46% and 52% of patients treated with cantharidin achieved complete molluscum clearance, respectively … [A32891, A32892] For its natural purpose, the male blister beetle secretes and presents the cantharidin to a female beetle as a copulatory gift during mating.
Mixtures: CANTHACUR PS %1,%5,%30 TOPIKAL SOLUSYON 7,5 ML, Cantharidin 1% / Podophyllum Resin 5% / Salicylic Acid 30%Categories: Heterocyclic Compounds, 2-Ring, Compounds used in a research, industrial, or household settingRucaparib
go.drugbank.com/drugs/DB12332ApprovedInvestigationalBy targeting the genetically-mutated cancer cells that lack a DNA repair mechanism, rucaparib causes cancer cell death and reduces tumour growth. … [A18745] Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexAmcipatricin
go.drugbank.com/drugs/DB12333Investigational) and liposomal amphotericin B. … SPK-843 doses of higher than 1.0 mg/kg of body weight exhibit no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone
Navitoclax
go.drugbank.com/drugs/DB12340InvestigationalNavitoclax is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins. It is a substance being studied in the treatment of lymphomas and other types of cancer.
Synonyms: (R)-4-(3-Morpholin-4-Yl-1-Phenylsulfanylmethyl-Propylamino)-N-(4-{4-[2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-Enylmethyl]-Piperazin-1-Yl}-Benzoyl)-3-TrifluoromethanesulfonylbenzenesulfonamideNilofabicin
go.drugbank.com/drugs/DB12347InvestigationalCG400549 has been used in trials studying the treatment of Skin Infection.
Categories: Heterocyclic Compounds, 1-Ring5-amino-1,3,4-thiadiazole-2-thiol
go.drugbank.com/drugs/DB12348InvestigationalATT has been investigated in Pulmonary Tuberculosis.
Categories: Heterocyclic Compounds, 1-RingPiclozotan
go.drugbank.com/drugs/DB12361InvestigationalPiclozotan has been investigated for the treatment of Parkinson's Disease.
Categories: Heterocyclic Compounds, 1-Ring, Serotonin 5-HT1 Receptor AgonistsVestronidase alfa
go.drugbank.com/drugs/DB12366ApprovedInvestigationalVestronidase alfa, or vestronidase alfa-vjbk, is a recombinant human lysosomal beta glucuronidase that is a purified enzyme produced by recombinant DNA technology in a Chinese hamster ovary cell line. … The enzyme is a homotetramer consisted of 4 monomers with 629 amino acids, and holds the same amino acid sequence as human beta-glucuronidase (GUS) [FDA Label].
AZD-3839
go.drugbank.com/drugs/DB12368InvestigationalAZD3839 has been used in trials studying the basic science of Safety, Tolerability, Alzheimer's Disease, and Blood Concentration.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSotrastaurin
go.drugbank.com/drugs/DB12369InvestigationalSotrastaurin has been used in trials studying the basic science and treatment of Uveal Melanoma, Richter Syndrome, Prolymphocytic Leukemia, Recurrent Mantle Cell Lymphoma, and Recurrent Small Lymphocytic Lymphoma, among others.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring