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Emicizumab
go.drugbank.com/drugs/DB13923ApprovedInvestigationalEmicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation Factor VIII and it has the capacity to bind simultaneously to activated Factor IX and Factor X. … Emicizumab was originated as an improved form of hBS23 and it was approved on November 16, 2017.[A31279, L1016] It was created by Chugai Pharmaceuticals Co.
Products: HEMLİBRA 150 MG/ 1 ML S.C. ENJEKSİYONLUK ÇÖZELTİ, 1 ADET, HEMLİBRA 30 MG/ 1 ML S.C. ENJEKSİYONLUK ÇÖZELTİ , 1 ADETPyridostigmine
go.drugbank.com/drugs/DB00545ApprovedInvestigational[A231009, A231014, L32413, L32418] Pyridostigmine was granted initial FDA approval on April 6, 1955, as an oral tablet. … Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in
International brands: Kalymin NCategories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersPlerixafor
go.drugbank.com/drugs/DB06809ApprovedInvestigationalPlerixafor is a small-molecule inhibitor of C-X-C chemokine receptor type 4 (CXCR4) that acts as a hematopoietic stem cell mobilizer. … [A7117] Compared to placebo with G-CSF, the plerixafor and G-CSF mobilization regimen has a higher probability of achieving the optimal CD34+ cell target for tandem transplantation in fewer apheresis procedures
Products: Mozofor 24 mg/1,2 mL S.C. Enjeksiyonluk Çözelti, 1 ADET, Lexeva 24 mg/1,2 mL S.C. Enjeksiyonluk Çözelti, 1 adetLevobupivacaine
go.drugbank.com/drugs/DB01002ApprovedInvestigationalWithdrawnIn particular, the specific levobupivacaine enantiomer is a worthwhile pursuit because it demonstrates less vasodilation and possesses a greater length of action in comparison to bupivacaine. … Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine.
Synonyms: (S)-1-butyl-2',6'-pipecoloxylidide, L-(-)-1-Butyl-2',6'-pipecoloxylidideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDipyridamole
go.drugbank.com/drugs/DB00975ApprovedInvestigationalA phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin.
Mixtures: AGGRENOX ® CAPSULAS DE LIBERACION RETARDADA, Aspirin and Extended - Release Dipyridamole Capsules, 25 mg / 200 mgCategories: P-glycoprotein inhibitors, P-glycoprotein substratesCaptopril
go.drugbank.com/drugs/DB01197ApprovedInvestigationalATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension. … Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).
Synonyms: D-2-methyl-3-mercaptopropanoyl-L-proline, D-3-mercapto-2-methylpropanoyl-L-prolineMixtures: CAPTOPRIL E IDROCLOROTIAZIDE HEXAL, CAPTOPRIL E IDROCLOROTIAZIDE SANDOZLamotrigine
go.drugbank.com/drugs/DB00555ApprovedInvestigationalLamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. … Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 countries.
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, P-glycoprotein inhibitorsSynonyms: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazineLarotrectinib
go.drugbank.com/drugs/DB14723ApprovedInvestigationalLarotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays … an important role in tumor cell growth and survival.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: VITRAKVI®CÁPSULAS DE 100MG, VITRAKVI 20 MG/ML ORAL ÇÖZELTİ, 2x50 MLDiazoxide
go.drugbank.com/drugs/DB01119ApprovedInvestigationalIn September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates. … Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.
Synonyms: 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxideCategories: Arteriolar Smooth Muscle, Agents Acting On, Cytochrome P-450 SubstratesPapaverine
go.drugbank.com/drugs/DB01113ApprovedInvestigationalIt is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. … An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions.
Categories: Heterocyclic Compounds, 2-Ring, Drugs Used in Erectile DysfunctionProducts: PAPAVERİN HCL GALEN 40 MG/2 ML IM/IV ENJEKSİYONLUK ÇÖZELTİ, 10 AMPUL, PAPAVERİN HCL GALEN 50 MG/2 ML IM/IV ENJEKSİYONLUK ÇÖZELTİ, 10 AMPUL