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All 5,925
Drugs 5,922
Targets 0
Indications 3
Pathways 0

Displaying results 4861 - 4870 of 5925 in total

Drug
Linerixibat
go.drugbank.com/drugs/DB11729
ApprovedInvestigational
Linerixibat is a first-in-class and small-molecule inhibitor of the ileal bile acid transporter (IBAT). On March 19, 2026, linerixibat was approved by the FDA for the treatment of cholestatic pruritus in patients with primary biliary cho...
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors
Drug
Danoprevir
go.drugbank.com/drugs/DB11779
Investigational
Danoprevir has been used in trials studying the treatment of Hepatitis C, Chronic.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors
Drug
Valbenazine
go.drugbank.com/drugs/DB11915
ApprovedInvestigational
Valbenazine is a modified metabolite of tetrabenazine, and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease. Tardive dyskinesi...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
Drug
Thiamylal
go.drugbank.com/drugs/DB01154
ApprovedVet approved
A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers
Drug
Cilostazol
go.drugbank.com/drugs/DB01166
ApprovedInvestigational
Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
Drug
Escitalopram
go.drugbank.com/drugs/DB01175
ApprovedInvestigational
Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic citalopram. It is used to restore serotonergic function in the treatment of depression and anxiety. Escitalopram is approximately 150 times ...
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
Drug
Propafenone
go.drugbank.com/drugs/DB01182
ApprovedInvestigational
An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: Nu-propafenone
Drug
Sparfloxacin
go.drugbank.com/drugs/DB01208
ApprovedWithdrawn
Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA top...
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 Inhibitors
Drug
Metipranolol
go.drugbank.com/drugs/DB01214
ApprovedWithdrawn
A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates
Drug
Estazolam
go.drugbank.com/drugs/DB01215
ApprovedIllicitInvestigational
A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates