Estazolam is a benzodiazepine used for the short-term management of insomnia. A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties.
- Mechanism
- Curator reviewed
Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
- Primary indication
- For the short-term management of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings.Curator reviewed · 1 structured indication
- Formula / weight
- C16H11ClN4 · 294.738 g/mol (avg)
- First approval
- Canada, 1993 · United States, 1990
- Code names
- ABBOTT-47631
Resolves to
CDCHDCWJMGXXRH-UHFFFAOYSA-NSMILESClC1=CC2=C(C=C1)N1C=NN=C1CN=C2C1=CC=CC=C1What you can answer from here — as of September 12, 2026
Which drugs share a target with Estazolam, and which of those have an active Phase 3 trial?
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